辅脂酶 来源于猪胰腺

基因脂肪酶（CLPS）编码一种主要在外分泌胰腺中表达的脂肪酶。这种蛋白质也存在于胃肠道中。它的结构包括17个氨基酸信号肽和一个位于N端的5氨基酸前体片段。

Research Area: Cell Signaling
Colipase is a member of a group of small cysteine-rich proteins characterized by a limited secondary structure. Its structure is relatively flat, measuring 25×30×35 Å, resembling an arrangement of protruding fingers interconnected at one end by a complex network of five disulfide bridges. The colipase structure comprises two small domains with closely related topology.

来自猪胰腺的大肠酶已用于：

• 脂肪酶测定的酶液
• 在酶混合物中模拟肠胃消化
• 作为明显关键因素之一，研究对番茄红素体外可及性的影响

脂质酶参与脂质代谢和凋亡信号通路。它对脂肪消化至关重要。作为一种胰腺蛋白，它可以防止脂肪酶变性，并能够附着在液滴的脂-水间相。脂质酶使脂肪酶可接近三酰甘油的内芯。外分泌胰腺功能不足引起的脂质酶分泌缺陷使膳食脂肪的腔内水解降至最低水平。缺乏先天性脂肪酶或脂质酶导致胰腺脂肪吸收不良。

Colipase, a small protein cofactor, is essential for efficient dietary lipid hydrolysis by pancreatic lipase. It attaches to the non-catalytic C-terminal domain of the lipase, stabilizing an active conformation and significantly enhancing the overall hydrophobic binding site. This pancreatic exocrine protein aids in the adsorption of pancreatic triglyceride lipase (PTL) to the substrate lipid-water interface.

以1.9-2.1 mg/mL浓度溶于水，形成透明、无色至淡黄色溶液。