质量水平
检测方案
≥93%
形式
powder
储存温度
−20°C
SMILES字符串
[Li+].[Li+].[Li+].CC(C)(COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16?,20-;;;/m1.../s1
InChI key
QSCBPHBAFBVXRK-HJKJOZROSA-K
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一般描述
辅酶A(CoA)由磷酸泛酸酯在泛酸激酶的作用下合成,是主要的调节剂。
应用
辅酶A三锂盐用于:
- 生成乙酰转移酶Gcn5酰化动力学分析的标准曲线
- 作为 JNADH 和 JNADPH 生产分析中的辅助因子
- 标记 Alexa647(AF647)探针
生化/生理作用
辅酶 A(CoA、CoASH、HSCoA)是促进酶促酰基转移反应,并支持脂肪酸合成和氧化的辅酶。CoA 参与多种酶的作用机制。酰基辅酶 A 积累与代谢紊乱有关,可能间接导致与碳诱导线粒体应激性心力衰竭、糖尿病和肥胖症相关的发病机制。
其他说明
有关更多技术信息和辅酶 A 衍生物的完整列表,请访问酰基转移试剂资源。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Structural basis for acyl-group discrimination by human Gcn5L2
Acta crystallographica. Section D, Structural biology, 72(7), 841-848 (2016)
Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
Nature Communications, 10(1), 1378-1378 (2019)
eLife, 10 (2021-09-30)
The complement system is a critical host defense against infection, playing a protective role that can also enhance disease if dysregulated. Although many consequences of complement activation during viral infection are well established, mechanisms that determine the extent to which
Characterization of Fluorescein Arsenical Hairpin (FlAsH) as a Probe for Single-Molecule Fluorescence Spectroscopy
Scientific reports, 7(1), 13063-13063 (2017)
Molecular genetics and metabolism, 94(1), 4-15 (2008-03-14)
Coenzyme A (CoA) sequestration, toxicity or redistribution (CASTOR) is predicted to occur in many hereditary and acquired conditions in which the degradation of organic acyl esters of CoA is impaired. The resulting accumulation of CoA esters and reduction of acetyl-CoA
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