Anti-CPSF3 (C-terminal) antibody produced in rabbit

Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. This gene is a member of the metallo-β-lactamase family and is referred as CPSF73 and CPSF-73. CPSF73 is a 73kDa subunit and is the pre-mRNA 3′-end-processing endonuclease.

Anti-CPSF3 (C-terminal) antibody produced in rabbit is suitable for western blotting at a dilution of 1:250-1:500 using K-562 lysate.

CPSF3 is induced by interaction between CSR1 and CPSF3 and is translocated from the nucleus to the cytoplasm, resulting in inhibition of polyadenylation. Down-regulation of CPSF3 using small interfering RNA induces cell death. CPSF73 mediates cleavage coupled to polyadenylation and histone pre-mRNA processing. HIV-1 Tat protein interacts with CPSF-73 and counteracts its repressive activity on the HIV-1 LTR promoter. During the cleavage and polyadenylation, CPSF plays a central role in processing the reaction.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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