C2618
细胞松驰素D
Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO
别名:
接柄孢菌素A
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关于此项目
经验公式（希尔记法）:
C30H37NO6
化学文摘社编号:
分子量:
507.62
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1632828
Quality Level
InChI key
SDZRWUKZFQQKKV-JHADDHBZSA-N
SMILES string
[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4
InChI
1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
biological source
Zygosporium mansonii
form
ready-to-use solution
concentration
5 mg/mL in DMSO
antibiotic activity spectrum
fungi
mode of action
enzyme | interferes
shipped in
wet ice
storage temp.
−20°C
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Application
细胞松弛素D是黑僵菌代谢物的同分异构体。细胞松弛素D具有抗菌和抗肿瘤活性。它还会有害于肌动蛋白丝的长时程增强作用(LTP)的维持。它与促进有利于肌动蛋白解聚的条件有关。
Biochem/physiol Actions
细胞渗透性真菌毒素；肌动蛋白聚合的有效抑制剂。破坏肌动蛋白微丝并激活p53依赖性通路，引起细胞周期在G1-S过渡期阻滞。抑制平滑肌收缩。抑制胰岛素刺激而非基础的葡萄糖转运。
肌动蛋白聚合的强效抑制剂；可破坏肌动蛋白微丝；激活p53依赖性通路；抑制平滑肌收缩；抑制胰岛素刺激的葡萄糖转运。
Other Notes
保持容器密闭，并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
188.6 °F - closed cup - Solvent
flash_point_c
87 °C - closed cup - Solvent
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
高风险级别生物产品--毒素类产品
此项目有
The inhibition of sugar transport in chick embryo fibroblasts by cytochalasin B. Evidence for a membrane-specific effect.
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The Journal of biological chemistry, 248(2), 711-719 (1973-01-25)
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The amounts of actin and myosin in rabbit neutrophils expressed as micrograms/10(6) cells are 5.6 +/- 0.75 and 0.56 +/- 0.08, respectively. The average value of the total actin in rabbit neutrophils under unstimulated conditions is distributed between Triton X-100
T L Rothstein
Journal of immunology (Baltimore, Md. : 1950), 136(3), 813-816 (1986-02-01)
B cells are stimulated to initiate DNA synthesis by modest doses of anti-immunoglobulin antibody in combination with cytochalasin. The ability of these agents to stimulate B cells in a sequential fashion was evaluated. Anti-immunoglobulin prepared cells to respond to subsequently
Giovanna Leoni et al.
The Journal of clinical investigation, 125(3), 1215-1227 (2015-02-11)
Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; therefore, a better understanding of the epithelial restitution process has
Sangbom Michael Lyi et al.
Virology, 456-457, 342-352 (2014-06-04)
Cell infection by parvoviruses requires that capsids be delivered from outside the cell to the cytoplasm, followed by genome trafficking to the nucleus. Here we microinject capsids into cells that lack receptors and followed their movements within the cell over
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