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C2538

Sigma-Aldrich

卡铂

别名:

顺 - 二氨基（1，1-环丁烷二羧酸）铂

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About This Item

线性分子式:
[C4H6(CO2)2]Pt(NH3)2
CAS号:
41575-94-4
分子量:
371.25
EC 号:
255-446-0
MDL编号:
MFCD00070464
UNSPSC代码:
12352200
PubChem化学物质编号:
24278303
NACRES:
NA.77

表单

powder

质量水平

100

抗生素抗菌谱

neoplastics

创始人

Bristol-Myers Squibb

SMILES字符串

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-L

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一般描述

卡铂被用于治疗睾丸癌、卵巢癌和乳腺癌。

应用

卡铂可用于：
  • 用于化疗性血小板减少小鼠模型及治疗
  • 诱导大量结直肠癌细胞死亡
  • 评估细胞增殖和化疗敏感性
  • 作为抑制细胞生长的阳性对照

生化/生理作用

卡铂是一种铂类抗肿瘤药物，通过与邻近的鸟嘌呤残基形成链内交联来破坏DNA。肿瘤通过DNA错配修复(MMR)活性的丧失以及由此导致的程序性细胞死亡诱导的减少而获得对这些药物的抗性。

特点和优势

该化合物是细胞凋亡研究的推荐产品。点击此处了解更多特色细胞凋亡产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。
该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发的化合物和已批准药物/候选药物的列表，请单击此处。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW1333
MKCT7823
MKCR3593
MKCR8746
MKCK1243

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Furqan Shaikh et al.
Pediatric blood & cancer, 60(4), 587-592 (2012-09-15)
While cisplatin is considered superior to carboplatin for the treatment of malignant germ cell tumors (MGCTs) in adults, pediatric oncology collaborative groups still remain concerned about the late effects of cisplatin in children. We performed a literature search to identify
Osteoblasts support megakaryopoiesis through production of interleukin 9
Xiao M, et al.
Blood, blood-b2016 (2017)
Joel Shapiro et al.
Annals of surgery, 258(5), 678-688 (2013-10-08)
To gain insight into the exact location of residual esophageal cancer in the esophageal wall and regional lymph nodes after neoadjuvant chemoradiotherapy (nCRT) and to determine the pattern of regression. Data from the recently published chemoradiotherapy for oesophageal cancer followed
Michael D Nyquist et al.
Cell reports, 31(8), 107669-107669 (2020-05-28)
Prostate cancers (PCs) with loss of the potent tumor suppressors TP53 and RB1 exhibit poor outcomes. TP53 and RB1 also influence cell plasticity and are frequently lost in PCs with neuroendocrine (NE) differentiation. Therapeutic strategies that address these aggressive variant
Mun Sem Liew et al.
BJU international, 112 Suppl 2, 74-82 (2013-10-30)
To review time-trends in the use of perioperative chemotherapy and its impact on oncological outcomes in patients with bladder urothelial cancer (UC) at a single tertiary institution. Using electronic and paper medical records, 89 patients were identified who underwent radical
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