所有图片(3)
别名:
顺 - 二氨基（1，1-环丁烷二羧酸）铂
线性分子式:
[C4H6(CO2)2]Pt(NH3)2
CAS号:
分子量:
371.25
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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一般描述
卡铂被用于治疗睾丸癌、卵巢癌和乳腺癌。
应用
卡铂可用于：
- 用于化疗性血小板减少小鼠模型及治疗
- 诱导大量结直肠癌细胞死亡
- 评估细胞增殖和化疗敏感性
- 作为抑制细胞生长的阳性对照
生化/生理作用
卡铂是一种铂类抗肿瘤药物，通过与邻近的鸟嘌呤残基形成链内交联来破坏DNA。肿瘤通过DNA错配修复(MMR)活性的丧失以及由此导致的程序性细胞死亡诱导的减少而获得对这些药物的抗性。
特点和优势
该化合物是细胞凋亡研究的推荐产品。点击此处了解更多特色细胞凋亡产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。
该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发的化合物和已批准药物/候选药物的列表，请单击此处。
警示用语：
Danger
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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商品
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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