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Merck
CN

C2517

Sigma-Aldrich

氯氮卓 盐酸盐

别名:

7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride

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About This Item

经验公式(希尔记法):
C16H14ClN3O · HCl
CAS号:
分子量:
336.22
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

药品控制

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

SMILES字符串

Cl[H].CNC1=Nc2ccc(Cl)cc2C(c3ccccc3)=[N+]([O-])C1

InChI

1S/C16H14ClN3O.ClH/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15;/h2-9H,10H2,1H3,(H,18,19);1H

InChI key

DMLFJMQTNDSRFU-UHFFFAOYSA-N

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生化/生理作用

The use of chlordiazepoxide during the first trimester might lead to congenital defects.

象形图

Health hazardExclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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D J Cash et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 704-711 (1997-11-14)
When rats were made tolerant to the benzodiazepine tranquilizer chlordiazepoxide (CDPX) by its steady administration, a particular gamma-aminobutyric acid type A (GABAA) receptor in cerebral cortex was modified. Its rate of desensitization in the absence of CDPX was enhanced (3-fold
Psychologists' psychotropic drug reference. (1999)
J K Pereira et al.
Life sciences, 65(10), PL101-PL107 (1999-09-28)
A single exposure to the elevated plus-maze test of anxiety reduces or abolishes the anxiolytic efficacy of benzodiazepines. The present study was designed to examine whether this phenomenon of "one-trial tolerance" resulted from a motivational deficit on trial 2. We
A Agmo et al.
Neuropharmacology, 37(2), 223-232 (1998-07-29)
Previous studies have shown that the opiate antagonist naloxone blocks the anxiolytic-like effects of benzodiazepines in several models of anxiety, including the elevated plus-maze. Although naloxone preferentially binds to the mu opioid receptor, its selectivity is rather low. The opioid

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