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C2401

单响尾蛇毒蛋白

Name: 单响尾蛇毒蛋白
Brand: SIGMA

Pulmotoxic, powder

别名:

(-)-野百合碱, 野百合碱

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₃NO₆

化学文摘社编号:

315-22-0

分子量:

325.36

NACRES:

NA.77

PubChem Substance ID:

24892326

UNSPSC Code:

12352200

MDL number:

MFCD00084656

Beilstein/REAXYS Number:

48732

Form:

powder

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属性

产品名称

单响尾蛇毒蛋白,

form

powder

mp

204 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3

InChI

1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1

InChI key

QVCMHGGNRFRMAD-XFGHUUIASA-N

说明

General description

野百合碱是属于吡咯烷嗪生物碱家族的大环化合物。这种成分在猪屎豆中天然存在。

Application

野百合碱已用于盐酸(HCl)注射液中，通过注入实验动物诱发肺动脉高压。

Biochem/physiol Actions

野百合碱可诱发大鼠肺血管综合征。这种成分具有公认毒性，可导致肝硬化、肝脏肿大、肝窦阻塞综合征和右心室肥大。野百合碱可抑制多种实验性肿瘤的生长.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H351

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

涉药品监管产品

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Integrated analysis of m6A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.

Yunhong Zeng et al.

Aging, 13(14), 18238-18256 (2021-07-27)

N6-methyladenosine (m6A) modification is one of the most common chemical modifications of eukaryotic mRNAs, which play an important role in tumors and cardiovascular disease through regulating mRNA stability, splicing and translation. However, the changes of m6A mRNA and m6A-related enzymes

Mechanisms and pathology of monocrotaline pulmonary toxicity.

D W Wilson et al.

Critical reviews in toxicology, 22(5-6), 307-325 (1992-01-01)

Monocrotaline (MCT) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale. Current hypotheses of the pathogenesis of MCT-induced pneumotoxicity suggest that MCT is activated

Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension.

Satoshi Matsuo et al.

The Journal of thoracic and cardiovascular surgery, 149(3), 902-909 (2014-12-03)

Lung ischemia-reperfusion (IR) injury during cardiopulmonary surgery is associated with postoperative morbidity and mortality, particularly in patients with pulmonary hypertension (PH). Using a rat model for monocrotaline-induced PH, we investigated the protective effect of rosuvastatin against IR injury in lungs

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