C2365
Clofilium tosylate
>97%, K+channel blocker, solid
别名:
4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium tosylate
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关于此项目
经验公式（希尔记法）:
C21H37ClN · C7H7O3S
化学文摘社编号:
分子量:
510.17
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Clofilium tosylate, >97%, solid
SMILES string
Cc1ccc(cc1)S([O-])(=O)=O.CCCCCCC[N+](CC)(CC)CCCCc2ccc(Cl)cc2
InChI key
MOQZYUUHIWPDQC-UHFFFAOYSA-M
InChI
1S/C21H37ClN.C7H8O3S/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20;1-6-2-4-7(5-3-6)11(8,9)10/h14-17H,4-13,18-19H2,1-3H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1
assay
>97%
form
solid
color
white
solubility
H2O: soluble
Quality Level
Biochem/physiol Actions
K+ channel blocker; cardiac depressant; anti-arrhythmic
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Sean A Misek et al.
Molecular pharmacology, 101(1), 1-12 (2021-11-05)
Most B-Raf proto-oncogene (BRAF)-mutant melanoma tumors respond initially to BRAF inhibitor (BRAFi)/mitogen-activated protein kinase kinase 1 inhibitor (MEKi) therapy, although few patients have durable long-term responses to these agents. The goal of this study was to use an unbiased computational
H Papp et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 67(5), 731-737 (2016-12-25)
Hyperventilation reduces partial pressure of CO
Wuyang Wang et al.
The Journal of cell biology, 216(6), 1715-1730 (2017-05-05)
The resting membrane potential (Δψ) of the cell is negative on the cytosolic side and determined primarily by the plasma membrane's selective permeability to K
Clofilium and other class III agents.
Steinberg, et al. et al.
Handbook of Experimental Pharmacology, 89, 389-389 (1989)
W B Gough et al.
Cardiovascular research, 23(6), 554-559 (1989-06-01)
To determine whether ischaemic tissue is more sensitive than normal tissue to class III anti-arrhythmic agents, we studied the effects of the class III agents clofilium, d-sotalol and bretylium on normal and ischaemic Purkinje fibres one day after ligation of
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