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Merck
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安全信息

C2276

Sigma-Aldrich

Z-Gly-Pro-Arg p-nitroanilide acetate salt

protease substrate

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100 μL
¥6,895.36

¥6,895.36

预计发货时间2025年4月28日详情

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100 μL
¥6,895.36

About This Item

经验公式（希尔记法）:
C27H34N8O7 · xC2H4O2
CAS号:
66648-35-9
分子量:
582.61 (free base basis)
MDL编号:
MFCD18782526
UNSPSC代码:
12352204
PubChem化学物质编号:
329774987
NACRES:
NA.32

¥6,895.36

预计发货时间2025年4月28日详情

获取大包装报价

质量水平

200

方案

≥98% (TLC)

表单

powder

溶解性

methanol: 20 mg/mL, clear, colorless to light yellow

储存温度

−20°C

SMILES字符串

CC(O)=O.NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OCc2ccccc2)C(=O)Nc3ccc(cc3)[N+]([O-])=O

InChI

1S/C27H34N8O7.C2H4O2/c28-26(29)30-14-4-8-21(24(37)32-19-10-12-20(13-11-19)35(40)41)33-25(38)22-9-5-15-34(22)23(36)16-31-27(39)42-17-18-6-2-1-3-7-18;1-2(3)4/h1-3,6-7,10-13,21-22H,4-5,8-9,14-17H2,(H,31,39)(H,32,37)(H,33,38)(H4,28,29,30);1H3,(H,3,4)/t21-,22-;/m0./s1

InChI key

FPMAXHHYPVIJMC-VROPFNGYSA-N

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Gene Information

human ... MBP(4155)

Gene Information

human ... MYC(4609)
mouse ... Myc(17869)
rat ... Myc(24577)

Gene Information

human ... MDM2(4193)
mouse ... Mdm2(17246)

Gene Information

human ... NEFH(4744)

species reactivity

guinea pig (weakly), mammals

species reactivity

rat (weakly), human, mouse (weakly)

species reactivity

mouse, human

species reactivity

chicken, Xenopus

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

isotype

IgG2b

isotype

IgG1

isotype

IgG2a

isotype

IgG1

应用

Z-Gly-Pro-Arg p-nitroanilide acetate salt has been used as a substrate in prostate-specific antigen (PSA) activation protease assay for determining enterokinase-PSA-trypsin (EK-PSA-TRP) activity and to perform kinetic experiments.[1] It has also been used as a substrate to measure the pancreatic trypsin activity chromogenically.[2]

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    BCCL3595
    BCCK2796
    BCCJ1071
    BCCG5036
    BCCL1247

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    Oliver C Rogers et al.
    Oncotarget, 9(32), 22436-22450 (2018-06-02)
    Prostate cancer is the most diagnosed malignancy and the second leading cause of cancer-related death in American men. While localized therapy is highly curative, treatments for metastatic prostate cancer are largely palliative. Thus, new innovative therapies are needed to target
    Constanze H Kubisch et al.
    American journal of physiology. Gastrointestinal and liver physiology, 291(2), G238-G245 (2006-04-01)
    Endoplasmic reticulum (ER) stress mechanisms have been found to play critical roles in a number of diseases states, such as diabetes mellitus and Alzheimer disease, but whether they are involved in acute pancreatitis is unknown. Here we show for the
    Constanze H Kubisch et al.
    American journal of physiology. Gastrointestinal and liver physiology, 291(2), G238-G245 (2006-04-01)
    Endoplasmic reticulum (ER) stress mechanisms have been found to play critical roles in a number of diseases states, such as diabetes mellitus and Alzheimer disease, but whether they are involved in acute pancreatitis is unknown. Here we show for the
    Jonathan M Bisaillon et al.
    American journal of physiology. Cell physiology, 298(5), C993-1005 (2010-01-29)
    We recently demonstrated that thapsigargin-induced passive store depletion activates Ca(2+) entry in vascular smooth muscle cells (VSMC) through stromal interaction molecule 1 (STIM1)/Orai1, independently of transient receptor potential canonical (TRPC) channels. However, under physiological stimulations, despite the ubiquitous depletion of

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