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方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
溶解性
DMSO: >20 mg/mL
创始人
Merck & Co., Inc., Kenilworth, NJ, U.S.
储存温度
−20°C
SMILES字符串
Oc1ccccc1C(=O)Nc2ccc(Cl)cc2CN3C(=O)c4ccccc4C3=O
InChI
1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)
InChI key
UFOUABRZSDGGAZ-UHFFFAOYSA-N
生化/生理作用
CPPHA is a positive allosteric modulator of mGluR5 receptor.
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
商品
DISCOVER Bioactive Small Molecules for Neuroscience
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