C223
Cirazoline hydrochloride
solid
别名:
2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride
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关于此项目
经验公式（希尔记法）:
C13H16N2O · HCl
化学文摘社编号:
分子量:
252.74
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
254-995-3
MDL number:
产品名称
Cirazoline hydrochloride, solid
InChI key
XFRXWLWUUDJHPB-UHFFFAOYSA-N
InChI
1S/C13H16N2O.ClH/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13;/h1-4,10H,5-9H2,(H,14,15);1H
SMILES string
Cl[H].C1CN=C(COc2ccccc2C3CC3)N1
form
solid
color
white
solubility
H2O: >35 mg/mL
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
Application
Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.
Biochem/physiol Actions
Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.
Features and Benefits
This compound is featured on the α1-Adrenoceptors and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Bronwyn A Evans et al.
Molecular pharmacology, 79(2), 298-307 (2010-10-28)
Although G protein-coupled receptors are often categorized in terms of their primary coupling to a given type of Gα protein subunit, it is now well established that many show promiscuous coupling and activate multiple signaling pathways. Furthermore, some agonists selectively
Aarthi Kamath et al.
The international journal of neuropsychopharmacology, 11(8), 1085-1096 (2008-05-08)
Neonatal ventral hippocampus (nVH) lesion in rats is a widely used animal model of schizophrenia due to the predominantly post-pubertal emergence of many schizophrenia-like behaviours. Our previous studies have shown increased ligand binding of alpha1 adrenergic receptors (AR) in the
Alasdair M Barr et al.
Neuropharmacology, 51(3), 457-465 (2006-06-10)
Iloperidone is a novel atypical antipsychotic which acts as a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist. To compare iloperidone behaviorally to other known antipsychotics, we evaluated the drug in three pharmacological models and one developmental model of disrupted prepulse inhibition (PPI)
J Pineda et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(2), 134-140 (1993-08-01)
Clonidine and related drugs not only interact with alpha 2-adrenoceptors but also recognise non-adrenoceptor sites in the brain. The involvement of these imidazoline-preferring receptors in the regulation of the activity of locus coeruleus noradrenergic neurones (NA-LC) was investigated after inactivation
Cirazoline
reference module in biomedical sciences (2016)
商品
Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.
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