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安全信息

C2175

Sigma-Aldrich

（酪氨酸[SO3H]27）胆囊收缩素片段26-33酰胺

≥97% (HPLC), powder

别名:

CCK-8, 促胰酶素C-末端八肽, 八肽胆囊收缩素, 辛卡利特

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About This Item

经验公式（希尔记法）:
C49H62N10O16S3
CAS号:
25126-32-3
分子量:
1143.27
Beilstein:
5231801
EC 号:
246-639-0
MDL编号:
MFCD00079849
UNSPSC代码:
51111800
PubChem化学物质编号:
24892470
NACRES:
NA.32

质量水平

200

方案

≥97% (HPLC)

表单

powder

UniProt登记号

P06307
P30551
P30553

储存温度

−20°C

SMILES字符串

CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

InChI

1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35?,36-,37-,38-,39-/m0/s1

InChI key

IZTQOLKUZKXIRV-IVVJSLGPSA-N

基因信息

human ... CCK(885)
rat ... Cckar(24889) , Cckbr(25706)

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Amino Acid Sequence

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2

一般描述

(Tyr[SO3H]27)胆囊收缩素片段26-33酰胺是由proCCK加工获得的八肽胆囊收缩素(CCK)硫酸盐。它存在于血浆和内分泌细胞中。

应用

(Tyr[SO3H]27)胆囊收缩素片段26-33酰胺已用于：
  • 研究其对胰腺炎中β5i/LMP7免疫蛋白酶体亚基的作用
  • 检测其对小窝(SL)和正常(NL)大鼠的胃排空、食物摄入和c-Fos免疫反应性的影响
  • 检测其对贝氏隆头鱼(Ballan Wrasse)肠和胆囊运动的影响

生化/生理作用

(Tyr[SO3H]27)胆囊收缩素片段26-33酰胺可激活胆囊收缩素B受体，介导阿片类药物镇痛的抑制作用。具有抗炎作用。介导对细胞因子释放、淋巴细胞和巨噬细胞的抑制作用。
神经递质；中枢神经系统和胃肠道中CCK的主要形式；可能会在饱腹感中发挥作用。

其他说明

胆囊收缩素的C末端八肽

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000311034
0000311034
0000300723
0000300743
0000300723

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