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等级
Biotechnology Performance Certified
质量水平
表单
powder
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
溶解性
ethanol: 50 mg/mL
抗生素抗菌谱
fungi
yeast
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
基因信息
human ... FKBP1A(2280) , PIN1(5300)
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应用
环己酰亚胺被广泛用于筛选抗 CHX 的酵母和真菌菌株，控制蛋白合成的抑制作用（用于检测短寿蛋白和蛋白表达的超诱导作用），并诱导细胞凋亡或通过死亡受体促进细胞凋亡。研究表明，它可以选择性清除动脉粥样硬化斑块中的巨噬细胞并激活无积聚的马卵母细胞。
生化/生理作用
作用机制：真核生物中的翻译抑制导致细胞生长停滞和细胞死亡。CHX被广泛用于抗CHX的酵母和真菌菌株的选择、蛋白质合成的受控抑制以检测短寿命蛋白质和蛋白质表达的超诱导作用、以及诱导凋亡或促进通过死亡受体诱导的凋亡。
活性谱：具有抑制酵母和真菌如念珠菌、曲霉、酵母菌和青霉的活性
活性谱：具有抑制酵母和真菌如念珠菌、曲霉、酵母菌和青霉的活性
环己酰亚胺（CHX）是灰色链霉菌产生的一种抗生素，可抑制真核生物中的蛋白质生物合成。它使参与肽链延伸的转移酶 II 失活。最近的研究表明，CHX 结合 60S 核糖体，并特异性地阻止了延伸过程中的易位步骤。
其他说明
保存于密闭容器内，置于干燥通风处。置于干燥处保存。
警示用语：
Danger
危险分类
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Tilman Schneider-Poetsch et al.
Nature chemical biology, 6(3), 209-217 (2010-02-02)
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains incompletely understood. The glutarimide portion of CHX is seen in a family of structurally related natural products including migrastatin, isomigrastatin and lactimidomycin
Mechanism of cycloheximide inhibition of protein synthesis in a cell-free system prepared from rat liver.
B S Baliga et al.
The Journal of biological chemistry, 244(16), 4480-4489 (1969-08-25)
Valerie Croons et al.
The Journal of pharmacology and experimental therapeutics, 320(3), 986-993 (2006-12-01)
Macrophages are an essential component of unstable atherosclerotic plaques and play a pivotal role in the destabilization process. We have demonstrated previously that local delivery of the mammalian target of rapamycin (mTOR) inhibitor everolimus selectively clears macrophages in rabbit plaques.
Y H Choi et al.
Reproduction (Cambridge, England), 122(1), 177-183 (2001-06-27)
Two different culture media (TCM-199 and follicular fluid), two activation treatments (10 and 50 micromol calcium ionophore l(-1)) and three culture periods with cycloheximide were evaluated to find effective culture conditions for activation of cumulus-free equine oocytes. Oocytes were collected
Nina Xue et al.
Cellular and molecular life sciences : CMLS, 76(17), 3433-3447 (2019-04-14)
Enhancement of insulin-like growth factor 1 receptor (IGF-IR) degradation by heat shock protein 90 (HSP90) inhibitor is a potential antitumor therapeutic strategy. However, very little is known about how IGF-IR protein levels are degraded by HSP90 inhibitors in pancreatic cancer
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