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一般描述
C1q与C1r、C1s以1:2:2的比例形成C1复合物，它是经典补体途径的第一组分。C1q由18条多肽链（六个A、六个B、六个C）组成（MW 460 kDa）。它们都含有一个由靠近N-末端的(Gly-Xaa-Yaa)重复序列组成的81-aa胶原样区域。三条链（A1B1C1）形成一个三螺旋，C端形成球状头部，其在结构和功能上可能是不同的结构域。
应用
补体成分C1q是血小板活化的重要调节因子。这一直是一个研究课题，因为血小板白细胞聚集在炎性疾病（如冠心病）中发挥着重要作用。特别是，C1q可抑制胶原蛋白诱导的聚集，提高活性氧（ROS）的产生。
生化/生理作用
无论是由于罕见的纯合子遗传缺陷还是转录/翻译缺陷，C1q缺乏几乎可以肯定是系统性红斑狼疮（SLE）的病因。这三个C1q亚基是通过一种新的转录同步机制表达的。
外形
是10 mM HEPES、300 mM NaCl、pH 7.2的溶液
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
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Macrophages in the injured spinal cord arise from resident microglia and infiltrating, peripherally derived monocytes. It is still not clear if macrophages derived from these two populations differ in their roles after CNS injury. The aims of this study are
Consol Farrera et al.
Journal of immunology (Baltimore, Md. : 1950), 191(5), 2647-2656 (2013-08-02)
Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens. However, in recent years, excessive NET formation has been implicated in several pathological conditions. Indeed, NETs that are not removed from tissues or from the circulation might serve to trigger
Christian S Lobsiger et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(46), E4385-E4392 (2013-10-31)
Accumulating evidence from mice expressing ALS-causing mutations in superoxide dismutase (SOD1) has implicated pathological immune responses in motor neuron degeneration. This includes microglial activation, lymphocyte infiltration, and the induction of C1q, the initiating component of the classic complement system that
Kusumam Joseph et al.
The Journal of biological chemistry, 288(18), 12753-12765 (2013-03-16)
Uncontrolled activation of the alternative complement pathway (AP) is thought to be associated with age-related macular degeneration. Previously, we have shown that in retinal pigmented epithelial (RPE) monolayers, oxidative stress reduced complement inhibition on the cell surface, resulting in sublytic
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The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 32(1), 98-105 (2012-11-13)
Sensitized heart transplant candidates are evaluated for donor-specific anti-HLA IgG antibody (DSA) by Luminex single-antigen bead (SAB) testing (SAB-IgG) to determine donor suitability and help predict a positive complement-dependent cytotoxicity crossmatch (CDC-XM) by virtual crossmatching (VXM). However, SAB testing used
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