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Merck
CN
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文件

安全信息

C1617

Sigma-Aldrich

c 反应蛋白 人

recombinant, expressed in E. coli, liquid

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别名:
CRP
MDL编号:
MFCD00130690
UNSPSC代码:
12352202
NACRES:
NA.32

重组

expressed in E. coli

质量水平

200

形式

liquid

分子量

23 kDa

bp

~100 °C

UniProt登记号

P02741

储存温度

2-8°C

基因信息

human ... CRP(1401)

一般描述

C 反应蛋白（CRP） 是一种均五聚体急性期炎症蛋白，主要在肝肝细胞中产生。这种高度保守的血浆蛋白还可由平滑肌细胞、巨噬细胞、内皮细胞、淋巴细胞和脂肪细胞产生。它属于正五聚蛋白家族。

应用

人类C反应蛋白已被用于:
  • 作为分化培养基的成分，用于研究 C 反应蛋白（CRP） 对肌管大小和肌管混合蛋白合成（MPS）的影响
  • 研究老年人血清CRP水平对人脐静脉内皮细胞（HUVEC）增殖的影响
  • 研究烟碱、单核细胞白细胞介素 6 (IL-6)、α7 烟碱型乙酰胆碱受体 （α7-nAChR）和 CRP 在冠状动脉痉挛 (CAS) 发展中的作用和联系

生化/生理作用

C-反应蛋白（CRP）在补体途径、细胞凋亡、吞噬作用、一氧化氮（NO）释放以及白细胞介素 6 和肿瘤坏死因子α的产生中起关键作用。它参与巨噬细胞中低密度脂蛋白的摄取。阑尾炎、胆囊炎、胰腺炎和脑膜炎患者的 CRP 水平升高。它在心血管疾病的病理生理学中起着至关重要的作用。。因此，它被用作感染和心血管事件的标志物。
C-反应蛋白 (CRP) 是一种能沉淀肺炎球菌细胞壁中 C-多糖的蛋白质。CRP 被广泛用作炎症状态的临床标志物，因为在炎症反应的急性期，肝细胞产生的 CRP 增加。

分析说明

一种高度纯化的蛋白质，通过发酵过程使用转基因 大肠杆菌制成。

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How is the protein concentration of product C1617, human recombinant C-Reactive Protein, determined?

    The absorbance of the solution at 280 nm is read and the protein concentration calculated using an E(1%) of 17.

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Adrian Hosford-Donovan et al.
Maturitas, 89, 52-57 (2016-05-18)
It is hypothesized that chronic systemic inflammation contributes to the age-related decline in cardiovascular function. The aim of the present study was to combine an assessment of the relationship between the serum level of C-reactive protein (CRP) and systolic and
Ming-Yow Hung et al.
Free radical biology & medicine, 120, 266-276 (2018-04-03)
Smoking and high-sensitivity C-reactive protein (hs-CRP) are risk factors for coronary artery spasm (CAS), which is characterized by the increased interleukin-6 (IL-6) level and monocyte counts; however, limited data are available regarding the role of cigarette-embedded nicotine in the modulation
P P Galanis et al.
Talanta, 238(Pt 2), 123056-123056 (2021-11-22)
We report the use of a laser-based fabrication process in the creation of paper-based flow-through filters that when combined with a traditional lateral flow immunoassay provide an alternative pathway for the detection of a pre-determined analyte over a wide concentration
Britta Wåhlin-Larsson et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(1), 267-278 (2017-11-14)
Mechanisms underlying the relationship between systemic inflammation and age-related decline in muscle mass are poorly defined. The purpose of this work was to investigate the relationship between the systemic inflammatory marker CRP and muscle mass in elderly and to identify
Ajay Kumar Yagati et al.
Bioelectrochemistry (Amsterdam, Netherlands), 128, 165-174 (2019-04-21)
Most clinical tests for biomarker detection require the support of a laboratory, and the results are usually slow, less sensitive, and lack the possibility for Point-of-Care (PoC) testing. Further, with the increasing demand for sensitive, portable, rapid, and low-cost devices
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