推荐产品
生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CCL17(6361)
一般描述
Chemokine (C-C motif) ligand 17 (CCL17) belonging to the CC chemokine family. It is also known as thymus and activation regulated chemokine (TARC), ABCD-2, SCYA17, A-152E5.3. It is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells.
免疫原
purified, E. coli-derived, recombinant human CCL-17.
应用
Anti-CCL17/TARC antibody produced in goat is suitable for the following applications:
- Immunohistochemistry using formalin-fixed and paraffin-embedded sections at a concentration of 5-15μg/mL.
- Neutralization
- Western blotting at a concentration of 0.1-0.2μg/mL
生化/生理作用
Thymus and activation regulated chemokine (TARC) may play an important role in T cell development as well as in trafficking and activation of mature T cells. It functions as a selective chemo-attractant for T cells that express a class of receptors binding TARC with high affinity and specificity. TARC acts as a functional ligand for CCR4, and CCR4 that are specific receptor for TARC selectively expressed on T cells. In Hodgkin lymphoma (HL) disease it is highly expressed and is a possible biomarker in HL patients. TARC expression is resistant to corticosteroid and is suppressed by PI3K enzyme inhibitors.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
13 - Non Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Karl J Staples et al.
The Journal of allergy and clinical immunology, 130(6), 1404-1412 (2012-09-18)
Studies with monocyte-derived macrophages (MDMs) and animal models have suggested a role for alternatively activated (M2) macrophages in asthmatic inflammation, but in vivo evidence for this phenotype in human asthma is lacking. To characterize the phenotype of lung macrophages from asthmatic
Maike Sauer et al.
American journal of hematology, 88(2), 113-115 (2012-12-12)
Hodgkin lymphoma (HL) has become one of the best curable cancers. However, better biomarkers are needed for outcome prediction that would allow protecting patients from over- or under-dosing of treatment. Thymus and activation-regulated chemokine/CCL17 (TARC) is highly and specifically elevated
T Imai et al.
The Journal of biological chemistry, 271(35), 21514-21521 (1996-08-30)
Precursors of most secreted and cell surface molecules carry signal sequences at their amino termini. Here we describe an efficient signal sequence trap method and isolation of a novel CC chemokine. An expression library was constructed by inserting 5' portion-enriched
T Imai et al.
The Journal of biological chemistry, 272(23), 15036-15042 (1997-06-06)
Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells. TARC functions as a selective chemoattractant for T cells that express a class of receptors
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