生物来源
algae (red)
质量水平
描述
Predominantly κ and lesser amounts of λ carrageenan
形式
powder
颜色
white to light brown
有效pH范围
7.5-10.5 (1.5% in water)
痕量阳离子
Ca: <3.5%
K: <11%
Na: <2.0%
适用性
suitable for gel preparation
储存温度
room temp
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一般描述
角叉菜胶是来自红藻细胞壁的粘多糖。 它们是由1，3α-1，4β-半乳聚糖组成的阴离子线性聚合物，每个二糖单元含有一个（κ-），两个（ι-）或三个（λ-）硫酸盐。 在离子溶液中，κ-和ι-角叉菜胶自缔合成螺旋结构，分别形成刚性或柔性凝胶。 λ-角叉菜胶不形成螺旋，并且不凝胶化。 角叉菜胶在商业上用作增稠剂和稳定剂。
应用
角叉菜胶被用来抑制体内和体外的免疫反应，其机制被认为涉及对巨噬细胞的选择性细胞病变作用。 由于ι-、κ-和λ-角叉菜胶具有不同程度的硫酸化，因此可以对它们在保护性、抗病毒性和免疫抑制活性方面的差异进行比较研究。
角叉菜胶被用来抑制体内和体外的免疫反应，其机制被认为涉及对巨噬细胞的选择性细胞病变作用。由于ι-、κ-和λ-角叉菜胶具有不同程度的硫酸化，因此可以对它们在保护性、抗病毒性和免疫抑制活性方面的差异进行比较研究。角叉菜胶可用于开发生物材料，如骨移植替代品；用于药物输送的截留容器，如生物芯和封装载体。角叉菜胶用于开发水凝胶。
制备说明
从各种海藻中混合制成刚性凝胶。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
植物油/植物胶产品
José A Fernández-Romero et al.
Antimicrobial agents and chemotherapy, 56(1), 358-368 (2011-11-09)
Topical microbicides that block the sexual transmission of HIV and herpes simplex virus 2 (HSV-2) are desperately needed to reduce the incidence of HIV infections worldwide. Previously we completed phase 3 testing of the carrageenan-based gel Carraguard. Although the trial
M L Weiner
Agents and actions, 32(1-2), 46-51 (1991-01-01)
Food-grade carrageenan is a safe natural product prepared from seaweed. Its addition to food imparts many desirable characteristics which have allowed it to be used continuously for centuries. The long safe history of this natural food additive is confirmed by
A W Thomson et al.
Agents and actions, 11(3), 265-273 (1981-05-01)
Carrageenans (kappa, lambda and iota) are sulphated polysaccharides isolated from marine algae that can markedly suppress immune responses both in vivo and in vitro. Impairment of complement activity and humoral responses to T-dependent antigens, depression of cell-mediated immunity, prolongation of
Ahu Uraz et al.
Journal of clinical and experimental dentistry, 5(1), e23-e29 (2014-01-24)
The objective of this study was to histologically and histomorphometrically evaluate the efficacy of the new formulations of eggshell-derived calcium carbonate in rats. The study was conducted on 30 adult male rats. Four standardized and circular intrabony defects were created
Immunopharmacology of the macrophage-toxic agent carrageenan.
A W Thomson et al.
International journal of immunopharmacology, 1(4), 247-261 (1979-01-01)
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