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Merck
CN
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文件

安全信息

C0984

Sigma-Aldrich

肌酸激酶 MB 组分 来源于人类心脏

≥70% (SDS-PAGE), liquid

别名:

CK MB Fraction

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About This Item

MDL编号:
MFCD00151686
UNSPSC代码:
12352204
NACRES:
NA.54

生物来源

human heart

质量水平

200

检测方案

≥70% (SDS-PAGE)

形式

liquid

浓度

≥0.5 mg/mL

技术

IR spectroscopy: suitable

适用性

suitable for tissue

UniProt登记号

P06732
P12277

应用

pharmaceutical

储存温度

−20°C

基因信息

human ... CKB(1152) , CKM(1158)

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一般描述

肌酸激酶（CK）由 M 和 B 亚基组成，是一种二聚合分子。它是一种 CK 同工酶。这种酶主要存在于心肌中。

应用

肌酸激酶 MB 同工酶 (MBCK) 可作为急性心肌梗死的诊断标志物。

生化/生理作用

肌酸激酶（CK）可催化从磷酸肌酸形成肌酸酐。CK-MB 血清水平升高是心肌细胞损伤的主要指标，被视作心肌梗死诊断的“金标准”。心肌肌钙蛋白 I（cTnI）或心肌肌钙蛋白 I 的水平也与 CK-MB 水平升高相关。慢性肾衰竭时 CK-MB 的水平也可能升高。

组分

溶于 5 mM 琥珀酸钠、10 mM 氯化钠、1 mM EDTA、5 mMβ-巯基乙醇，50% 甘油，pH 7.0。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What does the MB stand for in Product C0984, Creatine Kinase MB Fraction from human heart?

    Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain).

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin
Titus J, et al.
Communications medicine, 2 (2022)
J E Adams et al.
Clinical chemistry, 40(7 Pt 1), 1291-1295 (1994-07-01)
Although measurement of cardiac troponin I (cTnI) is, in some situations, more specific for detection of cardiac injury than is measurement of the MB isoenzyme of creatine kinase (MBCK), its sensitivity and specificity relative to MBCK for detection of myocardial
Creatine Kinase
Clinical Methods: The History, Physical, and Laboratory Examinations (1990)
Terry M Welsh et al.
Annals of clinical and laboratory science, 32(1), 44-49 (2002-02-19)
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin
L Gruberg et al.
The American journal of cardiology, 87(12), 1356-1360 (2001-06-09)
We evaluated the short- and long-term clinical outcomes of 326 consecutive patients with chronic renal failure, not on dialysis, who had creatine kinase (CK)-myocardial band (MB) fraction elevation after successful percutaneous coronary intervention in a native coronary artery. Based on
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Chromatograms

application for HPLC

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