推荐产品
产品名称
南蛇藤醇, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
red
溶解性
DMSO: >10 mg/mL
H2O: insoluble
储存温度
−20°C
SMILES字符串
CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(O)=O
InChI
1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
InChI key
KQJSQWZMSAGSHN-JJWQIEBTSA-N
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应用
使用雷公藤红素：
- 腹腔注射至试验小鼠研究其在非酒精性脂肪肝(NAFLD)中的作用
- 用在培养基中研究其对人角朊细胞培养基中脂多糖诱导的炎症损伤的影响
- 用于研究其在VCaP细胞体内和体外的作用
生化/生理作用
雷公藤红素是一种五嗪三萜烯,自然存在于雷公藤中。它对治疗类风湿性关节炎有效。雷公藤红素可阻止蛋白酶体和核因子Κb发挥作用。
雷公藤红素是一种强效抗氧化剂和抗炎剂。它是一种新的HSP90抑制剂（破坏Hsp90/Cdc37复合物），具有抗癌作用（抗血管生成-抑制血管内皮生长因子受体表达）；抗氧化剂（抑制脂质过氧化）和抗炎活性（抑制iNOS和炎性细胞因子的产生）。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells
Xiong Y, et al.
Biomedicine and Pharmacotherapy, 105, 798-804 (2018)
Erin M O'Leary et al.
Molecular genetics and metabolism, 107(1-2), 173-185 (2012-08-18)
Sialidosis is an autosomal recessive disorder caused by a dysfunctional Sialidase enzyme. Categorised into two phenotypes, Sialidosis type I and II, Sialidosis is a highly heterogeneous disorder with varying ages of onset and pathologies. Currently, there is no viable therapy
Mengfei Liu et al.
Nature communications, 12(1), 4560-4560 (2021-07-29)
Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we explore the mechanistic role of super-enhancers linking cytokine TNFα with chemokine
A C Allison et al.
Progress in neuro-psychopharmacology & biological psychiatry, 25(7), 1341-1357 (2001-08-22)
In the brains of patients with Alzheimer's disease (AD) signs of neuronal degeneration are accompanied by markers of microglial activation, inflammation, and oxidant damage. The presence of nitrotyrosine in the cell bodies of neurons in AD suggests that peroxynitrite contributes
Radhamani Kannaiyan et al.
Cancer letters, 303(1), 9-20 (2010-12-21)
Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology. Celastrol is one such compound that was originally identified from traditional Chinese medicine (Thunder of God Vine) almost three decades ago and
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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