C0733
环氧化酶 1 来源于绵羊
glycerol solution, ≥1500 units/mg protein
别名:
COX-1, Constitutive cyclooxygenase, Prostaglandin H synthase 1, Prostaglandin endoperoxide synthase
产品名称
环氧化酶 1 来源于绵羊, glycerol solution, ≥1500 units/mg protein
form
glycerol solution
specific activity
≥1500 units/mg protein
mol wt
dimer subunit mol wt 70 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
sheep ... COX1(808251)
Application
在骨关节炎样品的蛋白免疫印迹分析 和前列腺素合成酶活性测定中，来自绵羊的环氧合酶 1 已用作阳性对照蛋白。
Biochem/physiol Actions
COX-1 催化花生四烯酸转化为前列腺素 H 2 （前列腺素、血栓素和前列环素生物合成的第一步）。它参与类花生酸的稳态角色，并在几乎所有动物组织中组成性表达。其中，花生四烯酸的表观 K M 为 8.3μM 。
General description
环氧合酶 1 是一种分子量为 71 kDa 的膜结合蛋白，主要存在于内质网中。它有三个结构域，即表皮生长因子（EGF）样域、酶结构域和膜结合域。环氧合酶 1 介导前列腺素合成，并受抗炎非甾体药物调节。
Other Notes
在37°C下，一个单位在含 100μM花生四烯酸盐、5 mM EDTA、2 mM 苯酚和 1 μM血色素的 0.1 MTris-HCl 缓冲液 (pH 8) 中每分钟消耗 1 纳摩尔氧气。
Physical form
溶液溶于 80 mM Tris-HCl，pH 8，含 0.1% 吐温 ® 20，300μM 二乙基二硫代氨基甲酸酯和 10% 甘油。
Legal Information
TWEEN is a registered trademark of Croda International PLC
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
动植物源性产品
此项目有
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