Cell-Penetrating Peptides: Processes and Applications

This book fills the need for a comprehensive update concerning cell-penetrating peptides (CPPs), to which the drug molecule can attach and pass through the cell membrane. It covers classes of cell-penetrating peptides; mechanisms of cell penetration, interactions of cell-penetrating peptides with plasma membranes, and lipid models; and applications of cell-penetrating peptides. These divisions cover information from basic biochemistry to clinical application, including a description of the general rules for cellular uptake of the transport peptides. This overview will lead to better designed novel transport peptides to achieve successful application of CPPs.

CLASSES OF CELL-PENETRATING PEPTIDES
The Tat-Derived Cell-Penetrating Peptide
Penetratins
Transportans
MAP Peptides
Signal Sequence-Based Cell-Penetrating Peptides (NLS) and Their Applications for Gene Delivery
Hydrophobic Membrane Translocating Sequence (MTS) Peptides
Arginine-Rich Molecular Transporters for Drugs: The Role of Backbone and Sidechain Variations on Cellular Uptake
MECHANISMS OF CELL PENETRATION, INTERACTIONS OF CELL-PENETRATING PEPTIDES WITH PLASMA MEMBRANES AND LIPID MODELS
Interactions of Cell-Penetrating Peptides with Membranes
Structure Prediction of CPPs and Iterative Development of Novel CPPs
Biophysical Studies of Cell-Penetrating Peptides
Toxicity and Side-Effects of Cell-Penetrating Peptides
Quantification of Cell-Penetrating Peptides and Cargoes
Kinetics of Uptake of Cell-Penetrating Peptides
Signal Peptides,
APPLICATIONS OF CELL-PENETRATING PEPTIDES
Cell-Penetrating Peptide Conjugations and Magnetic Cell Labels
Cell-Penetrating Peptides as Vectors for Delivery of Nucleic Acids
Protein Transport
Microbial Membrane Permeating Peptides and Their Applications