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文件

C0609

Sigma-Aldrich

鼠尾草酸 来源于迷迭香

≥91%, powder

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别名:
（4AR，10aS）-5,6-二羟基-1,1-二甲基-7-丙-2-基-2,3,4,9,10,10a-六氢萘-4a-羧酸
经验公式（希尔记法）:
C20H28O4
CAS号:
3650-09-7
分子量:
332.43
MDL编号:
MFCD02259459
UNSPSC代码:
12352106
PubChem化学物质编号:
329774804
NACRES:
NA.25

质量水平

200

检测方案

≥91%

形式

powder

颜色

faintly yellow to dark yellow

运输

wet ice

储存温度

−20°C

SMILES字符串

CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O

InChI

1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1

InChI key

QRYRORQUOLYVBU-VBKZILBWSA-N

应用

来源于迷迭香的鼠尾草酸主要用于研究其作为抗氧化剂的机制如何防止脂质过氧化和蛋白质羰基化。可用于评估鼠尾草酸的神经保护活性，包括它调节 6-羟基多巴胺（6-OHDA）的神经毒性作用的能力。也可用于研究其抗癌潜力。
酚类化合物，天然具有抗氧化特性。抑制由 NADH 或 NADPH 氧化引起的脂质过氧化。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How does one prepare a stock solution of product C0609, Carnosic acid from Rosmarinus officinalis?

    A stock solution of C0609, Carnosic acid from Rosmarinus officinalis acid, can be prepared at 1 mg/ml in DMSO.

  6. At what final concentration can product C0609, Carnosic acid from Rosmarinus officinalis, be used?

    Product C0609, Carnosic acid from Rosmarinus officinalis, can be used at a final concentration of 0.1-1.0 μg/ml (equivalent to 0.3-3.0 micromoles per liter). This information comes from a study of the photoprotective potential of dietary antioxidants including carnosic acid in human dermal fibroblasts exposed to ultraviolet-A (UVA) light.

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Tayebeh Rezaie et al.
Investigative ophthalmology & visual science, 53(12), 7847-7854 (2012-10-20)
The herb rosemary has been reported to have antioxidant and anti-inflammatory activity. We have previously shown that carnosic acid (CA), present in rosemary extract, crosses the blood-brain barrier to exert neuroprotective effects by upregulating endogenous antioxidant enzymes via the Nrf2
A I Kuzmenko et al.
Journal of photochemistry and photobiology. B, Biology, 48(1), 63-67 (1999-04-17)
Lipid free-radical oxidation has been studied in vivo in the mitochondrial fractions of the liver of rats fed RoseOx (carnosic acid nutritional supplement) by measuring chemiluminescence. The kinetics of the lipid chemiluminescence in rats fed RoseOx are significantly different from
Riham Salah El Dine et al.
Journal of natural products, 72(11), 2019-2023 (2009-10-10)
A new farnesyl hydroquinone, ganomycin I (1), was isolated along with ganomycin B (2) from the chloroform extract of the fruiting bodies of the Vietnamese mushroom Ganoderma colossum. These compounds inhibited HIV-1 protease with IC50 values of 7.5 and 1.0
Mariano Walter Pertino et al.
Journal of natural products, 73(4), 639-643 (2010-04-03)
Carnosic acid (1) has been shown to possess gastroprotective activity in vitro and in vivo. However, little is known of the gastroprotective effect or cytotoxicity of carnosic acid gamma-lactone (3). To determine structure-activity relationships, a series of 17 esters of
Kishor S Jain et al.
Bioorganic & medicinal chemistry, 15(14), 4674-4699 (2007-05-25)
Coronary arterial diseases are responsible for more deaths than all other associated causes combined. Elevated serum cholesterol levels leading to atherosclerosis can cause coronary heart disease (CHD). Reduction in serum cholesterol levels reduces the risk for CHD, substantially. Medicinal chemists
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