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Merck
CN

C0406

Sigma-Aldrich

κ-酪蛋白 来源于牛奶

≥70% (PAGE), lyophilized powder

别名:

Kappa-Casein

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About This Item

CAS号:
EC 号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

bovine milk

质量水平

方案

≥70% (PAGE)

表单

lyophilized powder

技术

isoelectric focusing (IEF): suitable

储存温度

−20°C

SMILES字符串

[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

一般描述

酪蛋白占牛奶总蛋白的80%。κ-酪蛋白是牛奶中主要的过敏原之一。它是由半乳糖、半乳糖胺和唾液酸组成的糖基化蛋白。以三糖或四糖形式存在,根据连接的寡糖数目表现为不同的亚型。κ-酪蛋白具有疏水性N末端和亲水性C末端区域。

应用

κ-酪蛋白(来源于牛奶)已用于:
  • 作为标准品定量分析酪蛋白浓度,评估菌株水解HM Mozzarella奶酪中酪蛋白的能力
  • 制备LPS缺失母牛牛奶蛋白质以用于淋巴细胞增殖检测
  • 作为反相高效液相色谱法(RP-HPLC)标准品,用于定量分析脱脂牛奶样本中的κ-酪蛋白浓度

生化/生理作用

κ-酪蛋白(来自牛乳)是属于酪蛋白磷蛋白家族的免疫球蛋白E(IgE)结合表位。κ-酪蛋白对酪蛋白胶束悬液的静电和空间稳定性具有重要作用。它可抗钙沉淀,因此可稳定其他酪蛋白。κ-酪蛋白一直是通过基因修饰制造低苯丙氨酸牛奶的研究对象,这对患有苯丙酮尿症(PKU)等代谢性疾病的患者很重要。

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A study on bovine kappa-casein aggregation after the enzymatic action of chymosin.
Maria Eugenia Hidalgo., et al
Colloids Surf., 76, 556-563 (2010)
Aprianita Aprianita et al.
The Journal of dairy research, 81(2), 183-192 (2014-03-07)
This experiment was conducted to determine the effects of diets supplemented with cottonseed oil, Acacia mearnsii-condensed tannin extract, and a combination of both on composition of bovine milk. Treatment diets included addition of cottonseed oil (800 g/d; CSO), condensed tannin from
Hongjun Yu et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(41), E9560-E9569 (2018-09-28)
The protein disaggregase ClpB hexamer is conserved across evolution and has two AAA+-type nucleotide-binding domains, NBD1 and NBD2, in each protomer. In M. tuberculosis (Mtb), ClpB facilitates asymmetric distribution of protein aggregates during cell division to help the pathogen survive
Presence of functional, autoreactive human milk-specific IgE in infants with cow's milk allergy.
Jarvinen KM., et al.
Clinical and Experimental Allergy (2011)
Caterina Villa et al.
Comprehensive reviews in food science and food safety, 17(1), 137-164 (2018-01-01)
Cow milk allergy is one of the most common food allergies in early childhood and often persists through adult life, forcing an individual to a complete elimination diet. Milk proteins are present in uncounted food products, such as cheese, yogurt

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