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C0400

Sigma-Aldrich

卡莫司汀

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

别名:

1,3-双（2-氯乙基）-1-亚硝基脲, BCNU

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About This Item

经验公式（希尔记法）:
C5H9Cl2N3O2
CAS号:
154-93-8
分子量:
214.05
EC 号:
205-838-2
MDL编号:
MFCD00057706
UNSPSC代码:
12352200
PubChem化学物质编号:
24278289
NACRES:
NA.77

product name

卡莫司汀, ≥98%

质量水平

200

检测方案

≥98%

形式

(Oily liquid to amorphous solid)

mp

30 °C (lit.)

溶解性

ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow

创始人

Bristol-Myers Squibb

储存温度

−20°C

SMILES字符串

ClCCNC(=O)N(CCCl)N=O

InChI

1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

InChI key

DLGOEMSEDOSKAD-UHFFFAOYSA-N

基因信息

human ... GSR(2936)

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相关类别

一般描述

卡莫司汀是一种与芥子气有关的β-氯-亚硝基脲化合物，可用于化疗。它抑制DNA复制和DNA转录。

应用

卡莫司汀已用于选择表达MGMTP140K（一种泡沫病毒载体）的转导的细胞。它还已用于荧光激活细胞分选（FACS）分析，以测试细胞系对卡莫司汀的反应。

生化/生理作用

卡莫司汀是一种DNA烷化剂，可引起DNA链间交联。 可有效对抗胶质瘤和其他实体瘤。

特点和优势

该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
这种化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H300,H350,H360

预防措施声明

P201 - P301 + P310 + P330

危险分类

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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Ching-Hsiang Fan et al.
Biomaterials, 34(8), 2142-2155 (2012-12-19)
Current chemotherapeutic agents do not only kill tumor cells but also induce systemic toxicity that significantly limits their dosage. Focused ultrasound (FUS) in the presence of microbubbles (MBs) is capable of transient and local opening of the blood-brain barrier (BBB)
John Blazeck et al.
Biotechnology journal, 5(7), 647-659 (2010-02-13)
The advent of high throughput genome-scale bioinformatics has led to an exponential increase in available cellular system data. Systems metabolic engineering attempts to use data-driven approaches--based on the data collected with high throughput technologies--to identify gene targets and optimize phenotypical
W Stahl et al.
Chemical research in toxicology, 5(1), 106-109 (1992-01-01)
S-[(2-Chloroethyl)carbamoyl]glutathione (SCCG), a compound formed during the decomposition of BCNU in the presence of GSH, induces DNA damage in a human lymphoblastoid cell line. This GSH conjugate was shown by direct fast atom bombardment mass spectrometric analysis to transfer an
Mapping the human kinome in response to DNA damage
Owusu M, et al.
Testing, 26(3), 555-563 (2019)
Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection
Olszko ME, et al
Gene Therapy, 22(7), 591-591 (2015)
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