C0330
Ciprofibrate
别名:
2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
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关于此项目
经验公式（希尔记法）:
C13H14Cl2O3
化学文摘社编号:
分子量:
289.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
257-744-6
MDL number:
InChI key
KPSRODZRAIWAKH-UHFFFAOYSA-N
InChI
1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)
SMILES string
CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(O)=O
form
powder
storage temp.
2-8°C
Quality Level
Gene Information
human ... PPARA(5465)
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Biochem/physiol Actions
Peroxisome proliferator-activated receptor α (PPARα) agonist
signalword
Danger
hcodes
pcodes
Hazard Classifications
Carc. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Karen G Calfee-Mason et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(6), 2062-2073 (2008-03-14)
Peroxisome proliferators (PPs) are a diverse class of chemicals, which cause a dramatic increase in the size and number of hepatic peroxisomes in rodents and eventually lead to the development of hepatic tumors. Nuclear factor-kappaB (NF-kappaB) is a transcription factor
Wei Xie et al.
Archives of toxicology, 83(10), 909-924 (2009-06-23)
Perfluorooctanesulfonamides, such as N-ethyl perfluorooctanesulfonamidoethanol (N-EtFOSE), are large scale industrial chemicals but their disposition and toxicity are poorly understood despite significant human exposure. The hypothesis that subacute exposure to N-EtFOSE, a weak peroxisome proliferator, causes a redox imbalance in vivo
Zakaria El Kebbaj et al.
Endocrinology, 150(3), 1192-1201 (2008-10-25)
Seasonal obesity and fasting-associated hibernation are the two major metabolic events governing hepatic lipid metabolism in hibernating mammals. In this process, however, the role of the nuclear receptor known as peroxisome proliferator-activated receptor (PPAR)-alpha has not been elucidated yet. Here
Fatemeh Sharifpanah et al.
Stem cells (Dayton, Ohio), 26(1), 64-71 (2007-10-24)
Peroxisome proliferator-activated receptors (PPARalpha, -beta and -gamma) are nuclear receptors involved in transcriptional regulation of lipid and energy metabolism. Since the energy demand increases when cardiac progenitor cells are developing rhythmic contractile activity, PPAR activation may play a critical role
Alessandro Antonelli et al.
Experimental cell research, 317(11), 1527-1533 (2011-05-14)
Until now, no data are present about the effect of peroxisome proliferator-activated receptor (PPAR)α activation on the prototype Th1 [chemokine (C-X-C motif) ligand (CXCL)10] (CXCL10) and Th2 [chemokine (C-C motif) ligand 2] (CCL2) chemokines secretion in thyroid cells. The role
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