C0330
Ciprofibrate
别名:
2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
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关于此项目
经验公式（希尔记法）:
C13H14Cl2O3
化学文摘社编号:
分子量:
289.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
257-744-6
MDL number:
InChI key
KPSRODZRAIWAKH-UHFFFAOYSA-N
InChI
1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)
SMILES string
CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(O)=O
form
powder
storage temp.
2-8°C
Quality Level
Gene Information
human ... PPARA(5465)
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Biochem/physiol Actions
Peroxisome proliferator-activated receptor α (PPARα) agonist
signalword
Danger
hcodes
pcodes
Hazard Classifications
Carc. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Chae Hwa Kwon et al.
Toxicology, 244(1), 13-24 (2007-12-18)
Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists have been reported to induce apoptosis in a variety of cell types including renal proximal epithelial cells. However, the underlying mechanism of cell death induced by PPARgamma agonists has not been clearly defined in
Wei Xie et al.
Archives of toxicology, 83(10), 909-924 (2009-06-23)
Perfluorooctanesulfonamides, such as N-ethyl perfluorooctanesulfonamidoethanol (N-EtFOSE), are large scale industrial chemicals but their disposition and toxicity are poorly understood despite significant human exposure. The hypothesis that subacute exposure to N-EtFOSE, a weak peroxisome proliferator, causes a redox imbalance in vivo
Karen G Calfee-Mason et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(6), 2062-2073 (2008-03-14)
Peroxisome proliferators (PPs) are a diverse class of chemicals, which cause a dramatic increase in the size and number of hepatic peroxisomes in rodents and eventually lead to the development of hepatic tumors. Nuclear factor-kappaB (NF-kappaB) is a transcription factor
P Passilly et al.
Biochemical pharmacology, 58(6), 1001-1008 (1999-10-06)
The basic mechanism(s) by which peroxisome proliferators activate peroxisome proliferator-activated receptors (PPARs) is (are) not yet fully understood. Given the diversity of peroxisome proliferators, several hypotheses of activation have been proposed. Among them is the notion that peroxisome proliferators could
Zakaria El Kebbaj et al.
Endocrinology, 150(3), 1192-1201 (2008-10-25)
Seasonal obesity and fasting-associated hibernation are the two major metabolic events governing hepatic lipid metabolism in hibernating mammals. In this process, however, the role of the nuclear receptor known as peroxisome proliferator-activated receptor (PPAR)-alpha has not been elucidated yet. Here
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