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About This Item
经验公式（希尔记法）:
C162H262N50O52S2
CAS号:
分子量:
3806.25
MDL编号:
UNSPSC代码:
51111800
NACRES:
NA.32
推荐产品
生物来源
rat
质量水平
方案
≥95% (HPLC)
表单
powder
分子量
3803.25-3809.25 Da
技术
cell based assay: suitable
序列说明
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
储存温度
−20°C
基因信息
rat ... Calca(24241)
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Amino Acid Sequence
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
一般描述
Research area: Neuroscience
Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.
Calcitonin gene related peptide (CGRP) is a 37 amino acid neuropeptide. It exists in two isoforms α-CGRP and β-CGRP. CGRP is produced by the alternative splicing of the calcitonin gene (CALCA). They are primarily localized in the C and Aδ sensory fibers, but are also present in non-neuronal tissues, like the cardiovascular system.
应用
Calcitonin Gene Related Peptide rat has been used:
- To study its protective role in lipopolysaccharide (LPS)-induced acute lung injury (ALI).
- To examine the effects of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric lesions and mucosal barrier in stress induced rats.
- To mediate the complement component 5a (C5a) induced mechanical hypersensitivity by activating nerve fibers and influencing non-neuronal cell movement through its receptor.
生化/生理作用
Calcitonin gene related peptide (CGRP) is a potent vasodilator produced from sensory fibers, acting as transmitters in the peripheral and central nervous system, thereby exerting its role in regulating pain and cardiovascular activity. CGRPs play an important role in regulating systemic blood pressure, and microvascular dilatation and are associated with hyperemia. It stimulates edema in orofacial tissue and its activation in pancreatic β-cells increases plasma levels of pancreatic enzymes. In addition, CGRP also induces DNA synthesis and cell proliferation in endothelial cells.
Potent, long-lasting vasodilator.
Potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
其他说明
Lyophilized from 0.1% TFA in H2O
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Calcitonin gene-related peptide is a potent vasodilator
Brain SD, et al.
Nature, 313(5997), 54-54 (1985)
The Role of Calcitonin Gene Related Peptide (CGRP) in Neurogenic Vasodilation and Its Cardioprotective Effects
Kee Z, et al.
Frontiers in Physiology, 9, 1249-1249 (2018)
Calcitonin gene-related peptide: physiology and pathophysiology
F A Russell, et al.
Physiological Reviews, 94(4), 1099-1142 (2014)
Exogenous alpha-calcitonin gene-related peptide attenuates lipopolysaccharide-induced acute lung injury in rats
Yang W, et al.
Molecular Medicine Reports, 12(2), 2181-2188 (2015)
Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors
Warwick CA, et al.
Pain, 160(3), 702-711 (2019)
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