所有图片(4)
别名:
CDP-胆碱, CDP-胆酸钠, P′- [2-（三甲基氨基）乙基] 酯胞苷 5′-（三磷酸氢二钠）内盐单钠, 胞磷胆碱钠
经验公式（希尔记法）:
C14H25N4NaO11P2 · 2H2O
CAS号:
分子量:
546.34
Beilstein:
4110040
MDL编号:
UNSPSC代码:
41106300
PubChem化学物质编号:
NACRES:
NA.77
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生物来源
yeast
质量水平
检测方案
~98%
形式
solid
颜色
white
溶解性
H2O: 100 mg/mL
储存温度
−20°C
SMILES字符串
[Na+].C[N+](C)(C)CCOP([O-])(=O)OP([O-])(=O)OCC1OC([C@H](O)[C@@H]1O)N2C=CC(N)=NC2=O
InChI
1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9?,11-,12-,13?;/m1./s1
InChI key
YWAFNFGRBBBSPD-MBWJOHGMSA-M
一般描述
胞苷′5-二磷酸胆碱（CDP-胆碱）含有通过二磷酸桥连接的胞苷和胆碱。
应用
胞苷5′-二磷酸胆碱钠盐二水合物已被用作生理代谢物，用于通过液相色谱-质谱法（LC-MS / MS）鉴定肯尼迪途径（Kennedy pathway）中的吉西他滨二磷酸胆碱（GdPC）。
生化/生理作用
胞苷′5-二磷酸胆碱（CDP-胆碱）在磷脂酰胆碱的合成中起重要作用。它还参与神经递质乙酰胆碱的生物合成。CDP-胆碱对缺氧、脑缺血和创伤性脑损伤有治疗作用。它还对学习和记忆障碍、药物成瘾、老年痴呆症′和帕金森′病有治疗作用。
注意
吸湿
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Cytidine 5?-diphosphocholine (CDP-choline) in stroke and other CNS disorders
Adibhatla R M and Hatcher J F
Neurochemical Research, 30(1), 15-23 (2005)
Rao Muralikrishna Adibhatla et al.
Neurochemical research, 30(1), 15-23 (2005-03-11)
Brain phosphatidylcholine (PC) levels are regulated by a balance between synthesis and hydrolysis. Pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1alpha/beta) activate phospholipase A(2) (PLA(2)) and PC-phospholipase C (PC-PLC) to hydrolyze PC. PC hydrolysis by PLA(2) releases
M Z Onal et al.
Stroke, 28(5), 1060-1065 (1997-05-01)
Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently being assessed in clinical trials. To evaluate potential synergistic neuroprotective effects of prolonged citicoline treatment and early N-methyl-D-aspartate (NMDA) antagonist therapy, suboptimal treatment regimens of citicoline and MK-801
W R Schäbitz et al.
Journal of the neurological sciences, 138(1-2), 21-25 (1996-06-01)
Potential therapeutic effects of cytidine 5-diphosphocholine (citicoline), a key intermediary in the biosynthesis of the membrane phospholipid, phosphatidylcholine, are presumably related to enhanced phospholipid synthesis in the ischemic brain. We evaluated prolonged citicoline treatment in a temporary focal ischemia model.
W M Clark et al.
Neurology, 49(3), 671-678 (1997-09-26)
Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. It has been shown to produce beneficial effects in both animal models and non-US clinical stroke trials. This study comprised a
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