推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
种属反应性
rat, mouse, human
技术
immunoprecipitation (IP): 1:100
western blot: 1:1,000
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pThr14/pTyr15)
基因信息
human ... CDC2(983)
mouse ... Cdc2a(12534)
一般描述
Cdk1 is a regulatory protein that stimulates mitosis in eukaryotic cells. Phosphorylation of Thr14 and Tyr15 residues in Cdk1 causes its inactivation, which eventually results in the exit of cells from the mitotic cycle. Cdk1 may also be in involved in protein SUMOylation during cell cycle regulation . Anti-phospho-Cdk1 (p(Thr14)/p(Tyr15)) antibody is specific for rat, human and mouse Cdk1 (p(Thr14)/p(Tyr15)) and other cyclin-dependent kinases that are phosphorylated on these amino acid residues. The antibody does not bind with Cdk6 or Cdk4.
免疫原
synthetic phosphopeptide derived from the region of the human cdk (cyclin-dependent kinases) that contains threonine 14 and tyrosine 15.
应用
Anti-phospho-Cdk1 (p(Thr14)/p(Tyr15)) antibody is suitable for use in western blot (1:1,000), immunoblot (35kDa) and immunoprecipitation (1:100).
外形
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), containing 50% glycerol with 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
法规信息
含少量动物源组分生物产品
常规特殊物品
Yee-Fun Su et al.
PloS one, 7(4), e34250-e34250 (2012-04-18)
Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase phosphorylates
Yan Ma et al.
PloS one, 7(3), e33835-e33835 (2012-04-06)
Mitotic progression in eukaryotic cells depends upon the activation of cyclin-dependent kinase 1 (CDK1), followed by its inactivation through the anaphase-promoting complex (APC)/cyclosome-mediated degradation of M-phase cyclins. Previous work revealed that expression of a constitutively active CDK1 (CDK1AF) in HeLa
S Atherton-Fessler et al.
Molecular and cellular biology, 13(3), 1675-1685 (1993-03-01)
The kinase activity of human p34cdc2 is negatively regulated by phosphorylation at Thr-14 and Tyr-15. These residues lie within the putative nucleotide binding domain of p34cdc2. It has been proposed that phosphorylation within this motif ablates the binding of ATP
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门