所有图片(1)
About This Item
经验公式（希尔记法）:
C8H16ClNO2 · HCl
CAS号:
分子量:
230.13
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
>97% (GC)
表单
powder
储存条件
desiccated
颜色
white
mp
78-81 °C
溶解性
H2O: >5 mg/mL
ethanol: soluble
methanol: soluble
储存温度
−20°C
SMILES字符串
Cl[H].CCN(CCCl)CCOC(C)=O
InChI
1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H
InChI key
CHWPASAPXMNLKO-UHFFFAOYSA-N
应用
Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function.
生化/生理作用
Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM.
Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.
Acetylethylcholine mustard is an irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.
注意
Extremely hygroscopic.
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3
靶器官
Nervous system, Respiratory system
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
204.8 °F - closed cup
闪点(°C)
96 °C - closed cup
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Chatchada Sutalangka et al.
Journal of acupuncture and meridian studies, 6(5), 247-251 (2013-10-22)
The burden of Alzheimer's disease is continually rising globally, especially in the Asia-Pacific region. Unfortunately, the efficacy of the therapeutic strategy is still very limited. Because the effect of acupuncture at HT7 can improve learning and memory, the beneficial effect
Pennapa Chonpathompikunlert et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(3), 798-802 (2009-12-26)
Recently, numerous medicinal plants possessing profound central nervous system effects and antioxidant activity have received much attention as food supplement to improve cognitive function against cognitive deficit condition including in Alzheimer's disease condition. Based on this information, the effect of
Surapon N Charoensook et al.
Integrative biology : quantitative biosciences from nano to macro, 9(12), 956-967 (2017-11-24)
In vitro models of the neuromuscular junction (NMJ) are emerging as a valuable tool to study synaptogenesis, synaptic maintenance, and pathogenesis of neurodegenerative diseases. Many models have previously been developed using a variety of cell sources for skeletal muscle and
Yvonne L Dorland et al.
Scientific reports, 9(1), 14401-14401 (2019-10-09)
Culture expanded mesenchymal stromal cells (MSCs) are being extensively studied for therapeutic applications, including treatment of graft-versus-host disease, osteogenesis imperfecta and for enhancing engraftment of hematopoietic stem cells after transplantation. Thus far, clinical trials have shown that the therapeutic efficiency
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