B9935
BMS-345541
≥98% (HPLC), powder
别名:
N-（1,8-二甲基咪唑并[1,2-a] 喹喔啉-4-基）-1,2-乙二胺 盐酸盐
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C14H17N5 · HCl
化学文摘社编号:
分子量:
291.78
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
solubility
DMSO: 18 mg/mL, H2O: insoluble
originator
Bristol-Myers Squibb
storage temp.
2-8°C
SMILES string
Cl[H].Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1
InChI
1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H
InChI key
MIDKPVLYXNLFGZ-UHFFFAOYSA-N
Application
BMS-345541已用于：
- 作为IκB 激酶 (IKK) 复合抑制剂，研究其对由自然杀伤 (NK) 细胞产生的干扰素γ (IFN-γ)的影响
- 作为 IKK 抑制剂，研究其对牙龈成纤维细胞中嗜酸性粒细胞趋化因子和单核细胞趋化蛋白-1 (MCP-1) mRNA 表达的影响
- 作为核因子 κB (NF-κB) 通路抑制剂，研究其对在人口腔鳞状细胞癌细胞所产生的肿瘤坏死因子α （TNFα)的影响
Biochem/physiol Actions
BMS-345541是一种 IKB（IKK）变构位点抑制剂。
BMS-345541 具有抗炎特性。它还可以阻断促炎细胞因子的核因子 κB (NF-κB) 依赖性转录。BMS-345541具有抗炎活性，并在某些动物模型中起到阻止骨侵蚀的作用。
Features and Benefits
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，请点击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
Neety Sahu et al.
JCI insight, 7(20) (2022-10-05)
No disease-modifying drug exists for osteoarthritis (OA). Despite success in animal models, candidate drugs continue to fail in clinical trials owing to the unmapped interpatient heterogeneity and disease complexity. We used a single-cell platform based on cytometry by time-of-flight (cyTOF)
James R Burke et al.
The Journal of biological chemistry, 278(3), 1450-1456 (2002-10-31)
The signal-inducible phosphorylation of serines 32 and 36 of I kappa B alpha is critical in regulating the subsequent ubiquitination and proteolysis of I kappa B alpha, which then releases NF-kappa B to promote gene transcription. The multisubunit I kappa
Christina Ward et al.
Tissue barriers, 3(1-2), e982424-e982424 (2015-04-04)
NF-κB (p50/p65) is the best characterized transcription factor known to regulate cell responses to inflammation. However, NF-κB is also constitutively expressed. We used inhibitors of the classical NF-κB signaling pathway to determine whether this transcription factor has a role in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| B9935-25MG | 04061832823911 |
| B9935-5MG | 04061833444047 |