偶联物
biotin conjugate
质量水平
检测方案
≥97%
形式
solid
分子量
~15000 Da
溶解性
H2O: soluble 1 mg/mL, clear, colorless
储存温度
2-8°C
应用
肝素-生物素用于转染研究，用于开发自组装的三链体，例如聚酰胺基胺树枝状聚合物和DNA（PAMAM/DNA）肝素-生物素三链体，用于靶向基因转运，并改善转染。该三链体可用于固定蛋白质如乳铁蛋白和溶菌酶以及核酸。
其他说明
猪肠粘膜肝素偶联的生物素
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Qiao Zhang et al.
Bioconjugate chemistry, 21(11), 2086-2092 (2010-10-12)
To improve transfection efficiency and to incorporate target ligands to the gene delivery systems, heparin and heparin-biotin were introduced to complexes of polyamidoamine dendrimer and DNA (PAMAM/DNA) via electrostatic interactions to form self-assembled PAMAM/DNA/heparin and PAMAM/DNA/heparin-biotin terplexes, respectively. The self-assembled
Kelly M Kitchens et al.
Advanced drug delivery reviews, 57(15), 2163-2176 (2005-11-18)
This article summarizes our efforts to evaluate the potential of poly (amidoamine) (PAMAM) dendrimers as carriers for oral drug delivery. Specifically, the permeability of a series of cationic PAMAM-NH2 (G0-G4) dendrimers across Caco-2 cell monolayers was evaluated as a function
S Zou et al.
Comparative biochemistry and physiology. B, Comparative biochemistry, 103(4), 889-895 (1992-12-01)
1. Binding of biotin-heparin to immobilized lactoferrin and lysozyme was optimum at pH 6.0, 100 mM NaCl. Complex interactions between NaCl and CaCl2 concentrations were observed for heparin binding to both proteins. 2. The metal ions Cu2+, Zn2+, Fe2+ and
Nan Liu et al.
Die Pharmazie, 67(2), 174-181 (2012-04-20)
The efficiency and safety of gene delivery vectors were important factors for gene therapy. To enhance gene transfection efficiency and to incorporate biocompatible components to the polyamidoamine (PAMAM) dendrimer mediated gene delivery systems, human serum albumin (HSA) was introduced to
Dzmitry Shcharbin et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 110-127 (2009-10-10)
This paper reviews different techniques for analyzing the transfection efficiencies and cytotoxicities of dendriplexes-complexes of nucleic acids with dendrimers. Analysis shows that three plasmids are mainly used in transfection experiments: plasmid DNA encoding luciferase from the firefly Photinus pyralis, beta-galactosidase
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