B8429
抗Bax抗体，小鼠单克隆 小鼠抗
clone 6A7, purified from hybridoma cell culture
别名:
Anti-BCL2L4
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
6A7, monoclonal
Application:
ARR, IP, WB
Citations:
51
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6A7, monoclonal
form
buffered aqueous solution
mol wt
antigen 21 kDa (and possibly a dimer of 42 kDa)
species reactivity
mouse, rat, human
concentration
2 mg/mL
technique(s)
immunoprecipitation (IP): suitable, microarray: suitable, western blot: 10-60 μg/mL using extract of human breast adenocarcinoma MCF-7 cells, activated with dexamethasone
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BAX(581)
mouse ... Bax(12028)
rat ... Bax(24887)
General description
Bax是一种21kD的完整细胞器膜蛋白，它属于Bcl-2家族，并主要在线粒体中表达。Bax同源二聚体的形成加速凋亡死亡，而与Bcl-2或Bcl-xL异源二聚体化可以阻止凋亡。单克隆抗Bax抗体可用于研究在诱导凋亡时Bax蛋白的胞内重分布和其独特的亚细胞定位。该产品还可用于免疫印迹分析，以估计与凋亡信号通路相关的特定蛋白质表达的变化。小鼠抗Bax抗体与大鼠、小鼠和人Bax共有的氨基酸12-24中的表位发生特异性反应。
B细胞淋巴瘤2（BCL2）相关的X，凋亡调节子（BAX）可定位于人类染色体19q13.33上。
Immunogen
对应于人Bax序列中12-24位氨基酸的合成肽，其与KLH偶联。
Application
单克隆抗Bax抗体可以用于免疫细胞化学（稀释1: 1500）和蛋白质印迹。它也可被于微阵列和免疫沉淀。
小鼠抗Bax单克隆抗体可用于人类视网膜色素上皮细胞系、神经胶质瘤和乳腺癌细胞系的蛋白印迹检测中。
Biochem/physiol Actions
B细胞淋巴瘤2（BCL2）相关的X，凋亡调节子（BAX）基因的突变与大肠癌有关。BAX与卵巢滤泡功能障碍有关。
Physical form
溶于磷酸盐缓冲液 (pH 7.4) 中，含有 15 mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Sunny R Slone et al.
PloS one, 6(7), e21720-e21720 (2011-07-30)
Disruption of 14-3-3 function by alpha-synuclein has been implicated in Parkinson's disease. As 14-3-3s are important regulators of cell death pathways, disruption of 14-3-3s could result in the release of pro-apoptotic factors, such as Bax. We have previously shown that
Genetics of primary ovarian insufficiency: a review.
Fortuno C and Labarta E
Journal of Assisted Reproduction and Genetics, 31(12), 1573-1585 (2014)
Primary ovarian insufficiency.
De Vos M, et al.
Lancet, 376(9744), 911-921 (2010)
High-glucose Induces Retinal Pigment Epithelium Mitochondrial Pathways of Apoptosis and Inhibits Mitophagy by Regulating ROS/PINK1/Parkin Signal Pathway.
Yang Y, et al.
bioRxiv, 420653-420653 (2018)
Ning Yang et al.
Cell death & disease, 8(2), e2587-e2587 (2017-02-06)
Delocalized lipophilic cations (DLCs) selectively accumulate in cancer cell mitochondria and have long been explored for therapeutic applications. Although targeted effects to cancer cells are demonstrated in vitro, non-specific toxicities in vivo have hampered clinical development. Identifying the molecular mechanisms
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持