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安全信息

B8385

Sigma-Aldrich

苯丁抑制素 盐酸盐

powder, ≥98% (HPLC)

别名:

N-\ [(2S,3R)-3-氨基-2-羟基-4-苯基丁酰]- L -亮氨酸 盐酸盐

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选择尺寸

1 ML
CN¥1,500.33

CN¥1,500.33

国内现货，预计发货时间April 25, 2025详情

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1 ML
CN¥1,500.33

About This Item

经验公式（希尔记法）:
C16H24N2O4 · HCl
CAS号:
65391-42-6
分子量:
344.83
Beilstein:
4628066
MDL编号:
MFCD00058004
UNSPSC代码:
12352202
PubChem化学物质编号:
24278278
NACRES:
NA.77

CN¥1,500.33

国内现货，预计发货时间April 25, 2025详情

产品名称

苯丁抑制素 盐酸盐, ≥98% (HPLC)

生物来源

synthetic (organic)

质量水平

300

方案

≥98% (HPLC)

表单

powder

mp

216 °C

溶解性

water: 25 mg/mL, clear to very slightly hazy, colorless

抗生素抗菌谱

neoplastics

作用机制

enzyme | inhibits

储存温度

−20°C

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此商品
S188884100S0389
蔗糖 99% (GC), Vetec™, reagent grade

V900116

蔗糖

蔗糖 ≥99.5% (GC), BioReagent, suitable for cell culture, suitable for insect cell culture

S1888

蔗糖

蔗糖 suitable for microbiology, ACS reagent, ≥99.0%

84100

蔗糖

蔗糖 Molecular Biology, ≥99.5% (GC)

S0389

蔗糖

technique(s)

gas chromatography (GC): suitable

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

technique(s)

-

technique(s)

HPLC: suitable, cryopreservation: suitable, electron microscopy: suitable, enzyme immunoassay: suitable, gas chromatography (GC): suitable, immunohistochemistry: suitable

grade

reagent grade

grade

-

grade

ACS reagent

grade

for molecular biology

assay

99% (GC)

assay

≥99.5% (GC)

assay

≥99.0% (HPLC)

assay

≥99.5% (GC)

form

crystals

form

crystals

form

powder

form

crystals

mp

185-187 °C (lit.)

mp

185-187 °C (lit.)

mp

185-187 °C (lit.)

mp

185-187 °C (lit.)

product line

Vetec™

product line

BioReagent

product line

-

product line

-

一般描述

化学结构：氨基酸衍生物

生化/生理作用

一种氨肽酶选择性金属蛋白酶抑制剂。苯丁抑制素是亮氨酸氨基肽酶、氨基肽酶 B 和三氨基肽酶的竞争性和特异性抑制剂。在 60 nM 抑制氨肽酶 B（用精氨酸-β-萘胺为底物）和亮氨酸氨基肽酶在 20 nM（亮氨酸-β-萘胺为底物）。其显示对氨肽酶 A、胰蛋白酶、糜蛋白酶、弹性蛋白酶、木瓜蛋白酶、胃蛋白酶或溶血素无抑制作用。它有希望成为一种新型镇痛药，因为它能保护内源性阿片肽免受降解。

制备说明

在 25 mg/mL 水中进行溶解度试验，得到澄清溶液。预期 1 mM 储备液至少稳定 20°C 条件下储存 1 个月。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000386764
    0000306394
    0000306401
    0000306392
    0000306404

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    Hye Cheong Koo et al.
    International journal of molecular sciences, 22(8) (2021-05-01)
    It has been shown previously that a novel tetrapeptide, Arg-Leu-Tyr-Glu (RLYE), derived from human plasminogen inhibits vascular endothelial growth factor (VEGF)-induced angiogenesis, suppresses choroidal neovascularization in mice by an inhibition of VEGF receptor-2 (VEGFR-2) specific signaling pathway. In this study
    A Taylor
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 7(2), 290-298 (1993-02-01)
    Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates. They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Several
    Tina S Skinner-Adams et al.
    Journal of medicinal chemistry, 50(24), 6024-6031 (2007-10-27)
    Previous studies have pinpointed the M17 leucyl aminopeptidase of Plasmodium falciparum (PfLAP) as a target for the development of new antimalarials. This metallo-exopeptidase functions in the terminal stages of hemoglobin digestion and is inhibited by bestatin, a natural analog of
    Yekaterina Poloz et al.
    Eukaryotic cell, 11(4), 545-557 (2012-02-22)
    Bestatin methyl ester (BME) is an inhibitor of Zn(2+)-binding aminopeptidases that inhibits cell proliferation and induces apoptosis in normal and cancer cells. We have used Dictyostelium as a model organism to study the effects of BME. Only two Zn(2+)-binding aminopeptidases
    Anna L Epp et al.
    Scientific reports, 9(1), 9721-9721 (2019-07-07)
    The Pannexin 1 (Panx1) ion and metabolite channel is expressed in a wide variety of cells where it regulates a number of cell behaviours including proliferation and differentiation. Panx1 is expressed on the cell surface as well as intracellular membranes.
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