跳转至内容
Merck
CN
所有图片(2)

文件

安全信息

B8385

Sigma-Aldrich

苯丁抑制素 盐酸盐

≥98% (HPLC)

登录查看公司和协议定价
所有图片(2)
别名:
N-\ [(2S,3R)-3-氨基-2-羟基-4-苯基丁酰]- L -亮氨酸 盐酸盐
经验公式（希尔记法）:
C16H24N2O4 · HCl
CAS号:
65391-42-6
分子量:
344.83
Beilstein:
4628066
MDL编号:
MFCD00058004
UNSPSC代码:
12352202
PubChem化学物质编号:
24278278
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

300

检测方案

≥98% (HPLC)

形式

powder

mp

216 °C

溶解性

water: 25 mg/mL, clear to very slightly hazy, colorless

抗生素抗菌谱

neoplastics

作用机制

enzyme | inhibits

储存温度

−20°C

SMILES字符串

O=C(N[C@@H](CC(C)C)C(O)=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1.Cl[H]

InChI

1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1

InChI key

XGDFITZJGKUSDK-UDYGKFQRSA-N

正在寻找类似产品? 访问 产品对比指南

相关类别

一般描述

化学结构：氨基酸衍生物

生化/生理作用

一种氨肽酶选择性金属蛋白酶抑制剂。苯丁抑制素是亮氨酸氨基肽酶、氨基肽酶 B 和三氨基肽酶的竞争性和特异性抑制剂。在 60 nM 抑制氨肽酶 B（用精氨酸-β-萘胺为底物）和亮氨酸氨基肽酶在 20 nM（亮氨酸-β-萘胺为底物）。其显示对氨肽酶 A、胰蛋白酶、糜蛋白酶、弹性蛋白酶、木瓜蛋白酶、胃蛋白酶或溶血素无抑制作用。它有希望成为一种新型镇痛药，因为它能保护内源性阿片肽免受降解。

制备说明

在 25 mg/mL 水中进行溶解度试验，得到澄清溶液。预期 1 mM 储备液至少稳定 20°C 条件下储存 1 个月。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Hye Cheong Koo et al.
International journal of molecular sciences, 22(8) (2021-05-01)
It has been shown previously that a novel tetrapeptide, Arg-Leu-Tyr-Glu (RLYE), derived from human plasminogen inhibits vascular endothelial growth factor (VEGF)-induced angiogenesis, suppresses choroidal neovascularization in mice by an inhibition of VEGF receptor-2 (VEGFR-2) specific signaling pathway. In this study
A Taylor
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 7(2), 290-298 (1993-02-01)
Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates. They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytoplasm, and as membrane components. Several
Tina S Skinner-Adams et al.
Journal of medicinal chemistry, 50(24), 6024-6031 (2007-10-27)
Previous studies have pinpointed the M17 leucyl aminopeptidase of Plasmodium falciparum (PfLAP) as a target for the development of new antimalarials. This metallo-exopeptidase functions in the terminal stages of hemoglobin digestion and is inhibited by bestatin, a natural analog of
Michael B Harbut et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(34), E526-E534 (2011-08-17)
Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an excellent means of malaria control, drug-resistant parasites necessitate the discovery of new antimalarials. Peptidases are a promising class of drug targets and perform several important roles during the Plasmodium
Anastasios D Giannou et al.
Immunity, 56(1), 125-142 (2023-01-12)
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined the role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration and healing upon tissue damage, but it
查看所有相关文献

商品

ReadyShield Phosphatase and Protease Inhibitor Cocktail FAQ

ReadyShield® phosphatase and protease inhibitor cocktail FAQ for sample protection in a variety of cell types and tissue extracts, including mammalian, plant, and microbial samples. Our ReadyShield® Protease Inhibitor Cocktail is a non-freezing solution that contains inhibitors with a broad specificity for serine, cysteine, acid proteases and aminopeptidases.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门