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B7431

Sigma-Aldrich

苔藓抑素1

≥99%, solid

别名:

NSC 339555

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About This Item

经验公式（希尔记法）:
C47H68O17
CAS号:
83314-01-6
分子量:
905.03
MDL编号:
MFCD00893832
UNSPSC代码:
12352200
PubChem化学物质编号:
24891991
NACRES:
NA.77

质量水平

100

方案

≥99%

表单

solid

颜色

white

溶解性

DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES字符串

[H]\C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])C\C(=C(\[H])C(=O)OC)[C@H](OC(=O)\C=C\C=C\CCC)[C@@](O)(O4)C(C)(C)\C=C\[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C

InChI

1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1

InChI key

MJQUEDHRCUIRLF-TVIXENOKSA-N

应用

苔藓虫素1已用于研究其对小鼠结肠炎等自发性克罗恩病′（CD）的影响。它也已用于研究其作为驱虫药对大鼠中成年鼠管线虫感染的影响。

生化/生理作用

苔藓虫素(Bry1)是一种大环内酯。这种突触发生性化合物是从海洋苔藓虫多室草苔虫中获得的。Bry1能够逆转突触损失。它可以促进多种神经系统疾病动物模型中的突触成熟。当用于脑室给药时，它具有抗抑郁活性。现已确知Bry1参与保护细胞紧密连接（TJ）、抗炎功能和免疫调节。
从海洋苔藓虫 Bugula neritina 中分离的大环内酯可首先激活并随后下调蛋白激酶C（PKC）。其转移PKCδ 和ε的效果比佛波醇肉豆蔻酸乙酸酯更好。

其他说明

与水溶液中的玻璃和塑料结合

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
MKCV6265
MKCW8251
MKCW5054
MKCX0749
MKCW1351

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Yasuyuki Ogawa et al.
The Journal of organic chemistry, 78(1), 104-115 (2012-11-06)
The Prins cyclization of syn-β-hydroxy allylsilanes and aldehydes gives cis-2,6-disubstituted 4-alkylidenetetrahydropyrans as sole products in excellent yields regardless of the aldehyde (R″) or syn-β-hydroxy allylsilane substituent (R') used. By reversing the R″ and R' groups, complementary exocyclic stereocontrol can be
Dan Zhao et al.
Cellular immunology, 271(2), 392-400 (2011-09-10)
The majority of melanoma cells express detectable levels of HLA class II proteins, and an increased threshold of cell surface class II is crucial for the stimulation of CD4+ T cells. Bryostatin-1, a protein kinase C (PKC) activator, has been
N Kedei et al.
Biochemical pharmacology, 85(3), 313-324 (2012-11-14)
Bryostatin 1, like the phorbol esters, binds to and activates protein kinase C (PKC) but paradoxically antagonizes many but not all phorbol ester responses. Previously, we have compared patterns of biological response to bryostatin 1, phorbol ester, and the bryostatin
Gary E Keck et al.
Bioorganic & medicinal chemistry letters, 22(12), 4084-4088 (2012-05-15)
The role of the C(8) gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the
Tonia J Buchholz et al.
Chemistry & biology, 17(10), 1092-1100 (2010-11-03)
In vitro analysis of natural product biosynthetic gene products isolated from unculturable symbiotic bacteria is necessary to probe the functionalities of these enzymes. Herein, we report the biochemical characterization of BryR, the 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase (HMGS) homolog implicated in β-branching at
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