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Merck
CN

B7272

4-溴钙离子载体A23187

apoptosis inhibitor, powder

别名:

4-溴-A23187, 4-溴-钙霉素

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关于此项目

经验公式（希尔记法）:
C29H36BrN3O6
化学文摘社编号:
76455-48-6
分子量:
602.52
UNSPSC Code:
12352202
PubChem Substance ID:
24891982
NACRES:
NA.77
MDL number:
MFCD00077667

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产品名称

4-溴钙离子载体A23187, powder

SMILES string

CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O

InChI

1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1

InChI key

LDXQFZZGVTWFCF-FHYGWRBKSA-N

form

powder

color

yellow

solubility

ethanol: 20 mg/mL, DMSO: soluble

storage temp.

2-8°C

Quality Level

200

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相关类别

Application

4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.
非荧光Ca2+离子载体，可用于通过荧光探针校准细胞质游离Ca2+的定量。

Biochem/physiol Actions

4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.

Other Notes

Analog of calcium ionophore A23187

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000505179
0000505179
0000409156
0000362523
0000409156

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Calcium-influx increases SOD1 aggregates via nitric oxide in cultured motor neurons.
Kim HJ, et al.
Experimental & Molecular Medicine, 39(5), 574-574 (2007)
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Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 18(6), 626-636 (1999-02-05)
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A K Kiemer et al.
Immunology and cell biology, 79(1), 11-17 (2001-02-13)
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M E Kargacin et al.
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Kinetics of endogenous CaMKII required for synaptic plasticity revealed by optogenetic kinase inhibitor.
Murakoshi H, et al.
Neuron, 94(1), 37-47 (2017)
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