B7188
Blonanserin
≥98% (HPLC)
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关于此项目
经验公式（希尔记法）:
C23H30FN3
化学文摘社编号:
分子量:
367.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
XVGOZDAJGBALKS-UHFFFAOYSA-N
SMILES string
CCN1CCN(CC1)c2cc(-c3ccc(F)cc3)c4CCCCCCc4n2
InChI
1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥10 mg/mL
originator
Dainippon Sumitomo
storage temp.
room temp
Quality Level
Biochem/physiol Actions
Blonanserin is a D2/5-HT2 receptor antagonist; atypical antipsychotic.
Features and Benefits
This compound was developed by Dainippon Sumitomo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Tomomi Tenjin et al.
Human psychopharmacology, 27(1), 90-100 (2012-01-27)
The purpose of this study was to evaluate the effects of blonanserin, a novel antipsychotic, on cognitive function in first-episode schizophrenia. Twenty-four antipsychotic-naïve patients with first-episode schizophrenia participated in the study. Blonanserin was given in an open-label design for 8 weeks.
Three cases of schizophrenia showing improvement after switching to blonanserin.
Naohiro Kurotaki et al.
Psychiatry and clinical neurosciences, 65(4), 396-397 (2011-06-21)
Quetiapine-induced insulin resistance after switching from blonanserin despite a loss in both bodyweight and waist circumference.
Yutaro Suzuki et al.
Psychiatry and clinical neurosciences, 66(6), 534-535 (2012-10-17)
Ming Peng et al.
Journal of chromatographic science, 50(8), 727-732 (2012-05-19)
Blonanserin is a novel atypical antipsychotic agent for the treatment of schizophrenia. Ethyl alcohol, isopropyl alcohol and toluene are utilized in the synthesis route of this bulk drug. A new validated gas chromatographic (GC) method for the simultaneous determination of
Tomoko Inoue et al.
Progress in neuro-psychopharmacology & biological psychiatry, 39(1), 156-162 (2012-06-14)
Although blonanserin, a novel atypical antipsychotic agent with dopamine D(2)/serotonin 5-HT(2A) antagonistic properties, displays good brain distribution, the mechanism of this distribution has not been clarified. P-glycoprotein [(P-gp) or multidrug resistance protein 1 (MDR1)] is an efflux transporter expressed in
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