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Merck
CN
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安全信息

B7005

Sigma-Aldrich

倍他米松

≥98%

别名:

9α-氟-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16β-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮, 9α-氟-16β-甲基泼尼松龙

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About This Item

经验公式（希尔记法）:
C22H29FO5
CAS号:
378-44-9
分子量:
392.46
EC 号:
206-825-4
MDL编号:
MFCD00062969
UNSPSC代码:
51111800
PubChem化学物质编号:
57653954
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

100

无菌性

non-sterile

方案

≥98%

表单

powder

mp

235-237 °C (lit.)

溶解性

water: 0.063 g/L at 37 °C

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key

UREBDLICKHMUKA-DVTGEIKXSA-N

基因信息

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

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应用

Betamethasone has been used as a corticosteroid (CORT) standard.

生化/生理作用

Betamethasone, an isomer of dexamethasone is also termed as 9α-fluoro-16β-methyl-11 β,17,21-trihydroxypregna-1,4-dien-3,20-dione or 9α-fluoro-16β-methylprednisolone (27.1.52). It can be used as an anti-itch agent and treating dermatitis and eczema.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360FD,H373

危险分类

Repr. 1B - STOT RE 2

靶器官

Liver,Kidney,Endocrine system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number
BCCL9085
BCCC7478
BCBT3627
MKBR7502V
SLBG9665V

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Corticosteroids
Synthesis of Essential Drugs, 349-363 (2006)
Ceá C Tillis et al.
American journal of physiology. Lung cellular and molecular physiology, 300(6), L940-L950 (2011-03-15)
Adequate expression of surfactant protein-B (SP-B) is critical in the function of pulmonary surfactant to reduce alveolar surface tension. Expression of SP-B mRNA is restricted to specific lung-airway epithelial cells, and human SP-B mRNA stability is increased in the presence
A versatile liquid chromatography-tandem mass spectrometry system for the analysis of different groups of veterinary drugs.
Munoz, P. et al.
Analytica Chimica Acta, 529(1), 137-144 (2005)
Jennifer J P Collins et al.
American journal of physiology. Lung cellular and molecular physiology, 304(6), L438-L444 (2013-01-22)
Inflammation and antenatal glucocorticoids, the latter given to mothers at risk for preterm birth, affect lung development and may contribute to the development of bronchopulmonary dysplasia (BPD). The effects of the combined exposures on inflammation and antenatal glucocorticoids on transforming
Hanna Norberg et al.
The Journal of pediatrics, 163(3), 711-716 (2013-05-09)
To determine the relationship between repeat courses of antenatal corticosteroids (ACS) and risk factors for cardiovascular disease in adolescents and young adults. We assessed body mass index, blood pressure, arterial stiffness, blood lipids, and insulin resistance (IR) in a Swedish
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