B6889
1(S),9(R)-(−)-Bicuculline methiodide
solid
别名:
(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
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关于此项目
经验公式（希尔记法）:
C21H20INO6
化学文摘社编号:
分子量:
509.29
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
5419649
MDL number:
产品名称
1(S),9(R)-(−)-Bicuculline methiodide, solid
InChI key
HKJKCPKPSSVUHY-GRTNUQQKSA-M
SMILES string
[I-].[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@]4([H])c5cc6OCOc6cc5CC[N+]4(C)C
InChI
1S/C21H20NO6.HI/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m0./s1
form
solid
color
white to tan
solubility
H2O: 10 mg/mL
storage temp.
2-8°C
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Biochem/physiol Actions
GABAA receptor antagonist; blocks Ca2+-activated potassium (SK) channels. Water soluble derivative of (+)-bicuculline
法规信息
新产品
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S W Johnson et al.
Neuroscience letters, 231(1), 13-16 (1997-08-01)
Apamin, a bee venom toxin which blocks a Ca2+-dependent K+ current, potentiates N-methyl-D-aspartate (NMDA)-induced burst firing in dopamine neurons. We now report that burst firing is also potentiated by an apamin-like effect of bicuculline methiodide (BMI) at the same concentration
M Avoli et al.
Canadian journal of physiology and pharmacology, 75(5), 526-534 (1997-05-01)
This paper describes some functional and pharmacological properties of GABA-mediated mechanisms in the human neocortex maintained in vitro in a slice preparation. Neocortical neurons recorded intracellularly under normal conditions generate stimulus-induced and spontaneous potentials that are mediated by the activation
M Chebib et al.
Clinical and experimental pharmacology & physiology, 26(11), 937-940 (1999-11-24)
1. In the mammalian central nervous system, GABA is the main inhibitory neurotransmitter. GABA is a highly flexible molecule and, thus, can exist in many low-energy conformations. Conformationally restricted analogues of GABA have been used to help identify three major
D Strøbaek et al.
British journal of pharmacology, 129(5), 991-999 (2000-03-01)
Three genes encode the small-conductance Ca(2+)-activated K(+) channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the pharmacology of these subtypes using whole-cell patch clamp recordings. The bee venom peptide apamin blocked hSK1
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