所有图片(3)
别名:
γ,4-二羟基-2-(6-羟基-1-庚烯基)-4-环戊烯丁烯酸λ-内酯, Ascotoxin, BFA, 布雷菲德菌素 A, 烟碱
经验公式（希尔记法）:
C16H24O4
CAS号:
分子量:
280.36
Beilstein:
25191
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.52
推荐产品
生物来源
Penicillium brefeldianum
质量水平
等级
for molecular biology
产品线
BioXtra
检测方案
≥99% (HPLC and TLC)
形式
powder
分子量
280.36
溶解性
DMSO: 10 mg/mL (Store stock solutions at -20 °C)
抗生素抗菌谱
neoplastics
作用机制
protein synthesis | interferes
储存温度
2-8°C
SMILES字符串
C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1
InChI
1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
InChI key
KQNZDYYTLMIZCT-KQPMLPITSA-N
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一般描述
化学结构：大环内酯
布雷菲德菌素可诱导CtBP1/BARS蛋白的ADP核糖基化，从而调节胞内运输和分泌蛋白从内质网到高尔基体的运动。
应用
适用于分泌蛋白和细胞内转运机制的分子生物学研究
生化/生理作用
布雷菲德菌素A（BFA）是一种会破坏高尔基体的结构和功能的真菌代谢产物。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。
原理
布雷菲德菌素是一种真菌代谢产物，可通过破坏高尔基体来破坏真核细胞中的蛋白质分泌。它不会影响蛋白质合成过程。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
Y Misumi et al.
The Journal of biological chemistry, 261(24), 11398-11403 (1986-08-25)
We examined the effect of brefeldin A, an antiviral antibiotic, on protein synthesis, intracellular processing, and secretion in primary culture of rat hepatocytes. The secretion was strongly blocked by the drug at 1 microgram/ml and higher concentrations, while the protein
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Emma M Haapaniemi et al.
Blood, 125(4), 639-648 (2014-10-29)
The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development of immunodysregulation polyendocrinopathy enteropathy X-linked-like syndrome. Here, we immunologically characterized 3 patients
Anniek B van der Waart et al.
Blood, 124(23), 3490-3500 (2014-10-23)
Effective T-cell therapy against cancer is dependent on the formation of long-lived, stem cell-like T cells with the ability to self-renew and differentiate into potent effector cells. Here, we investigated the in vivo existence of stem cell-like antigen-specific T cells
Laura Jeanbart et al.
Cancer immunology research, 2(5), 436-447 (2014-05-06)
The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many solid tumors and is altered via tumor-derived factors that support tumor progression and metastasis. tdLNs are often removed surgically, and therapeutic vaccines against tumor antigens are
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