所有图片(1)
About This Item
经验公式（希尔记法）:
C25H24N4O2 · HCl
CAS号:
分子量:
448.94
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
synthetic (organic)
质量水平
方案
≥95%
表单
solid
溶解性
methanol: 10 mg/mL, clear, orange to red
储存温度
2-8°C
SMILES字符串
Cl.CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
InChI
1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H
InChI key
XRAMWNCMYJHGGH-UHFFFAOYSA-N
一般描述
GF 109203X可防止胶原蛋白触发的腺苷和三磷酸（ATP）分泌。它还可抑制胶原蛋白和α-凝血酶诱导的血小板聚集。它可作为糖原合成酶激酶-3（GSK-3）的抑制剂。GF 109203X也可作为一种抗炎剂。
应用
GF 109203X盐酸盐已被用于在人神经母细胞瘤衍生的kelly细胞中抑制蛋白激酶C。
生化/生理作用
蛋白激酶C的抑制剂；GSK-3的有效抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Phorbol-ester mediated suppression of hASH1 synthesis: multiple ways to keep the level down
Benko E, et al.
Frontiers in Molecular Neuroscience, 4(1), 1-1 (2011)
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
Toullec D1, et al.
The Journal of Biological Chemistry, 266(24), 15771-15781 (1991)
Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino) propyl]-1H-indol-3-yl]-4 (1H-indol-3-yl)-1H-pyrrole-2, 5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model
Kuchera S, et al.
Agents and Actions, 39(1), C169-C173 (1993)
The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity
Hers I, et al.
Febs Letters, 460(3), 433-436 (1999)
D Toullec et al.
The Journal of biological chemistry, 266(24), 15771-15781 (1991-08-25)
Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory concentration (IC50) of 10 nM. Nevertheless, this natural product is poorly selective when assayed against other protein kinases. In order to
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