生物来源
Penicillium brefeldianum
质量水平
蒸汽压
0.56 hPa ( 20 °C)
形式
solution
自燃温度
301 °C
浓度
10 mg/mL in DMSO
溶解性
DMSO: 10 mg/mL
抗生素抗菌谱
neoplastics
作用机制
cell membrane | interferes
运输
wet ice
储存温度
2-8°C
SMILES字符串
C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1
InChI
1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1
InChI key
KQNZDYYTLMIZCT-KQPMLPITSA-N
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应用
布雷正青霉菌产生的布雷菲德菌素A可用于研究高尔基复合体与细胞表面之间的蛋白和脂质转运。
生化/生理作用
布雷菲德菌素A（BFA）是一种会破坏高尔基体的结构和功能的真菌代谢产物。BFA是鞘磷脂循环的一种激活剂。已在人类肿瘤细胞中观察到了布雷菲德菌素A介导的细胞凋亡。
布雷菲德菌素A（BFA）是一种真菌代谢产物，可通过抑制蛋白质从ER到高尔基体的转运并诱导蛋白从高尔基体到内质网的逆行转运来破坏高尔基体的结构和功能。BFA抑制鞘磷脂向哺乳动物细胞表面的转运。BFA的酯衍生物表现出抗癌特性。
其他说明
保存于密封容器内，置于干燥通风处。在惰性气体下储存。吸湿性。储存类别（TRGS 510）：可燃液体
WGK
WGK 2
闪点(°F)
188.6 °F
闪点(°C)
87 °C
个人防护装备
Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)
A van Helvoort et al.
Journal of cell science, 110 ( Pt 1), 75-83 (1997-01-01)
Sphingomyelin is a major lipid of the mammalian cell surface. The view that sphingomyelin, after synthesis in the Golgi lumen, reaches the outer leaflet of the plasma membrane on the inside of carrier vesicles has been challenged by inconsistencies in
Antiviral activity of brefeldin A and verrucarin A.
G Tamura et al.
The Journal of antibiotics, 21(2), 160-161 (1968-02-01)
Marco Lepore et al.
Nature communications, 5, 3866-3866 (2014-05-17)
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic MHC class I-like molecule MR1. Here we show that human MAIT cells are remarkably oligoclonal in both the
Priya Rajavelu et al.
The Journal of clinical investigation, 125(5), 2021-2031 (2015-04-14)
Epithelial cells that line the conducting airways provide the initial barrier and innate immune responses to the abundant particles, microbes, and allergens that are inhaled throughout life. The transcription factors SPDEF and FOXA3 are both selectively expressed in epithelial cells
Jan H Reiling et al.
Nature cell biology, 15(12), 1473-1485 (2013-11-05)
Treatment of cells with brefeldin A (BFA) blocks secretory vesicle transport and causes a collapse of the Golgi apparatus. To gain more insight into the cellular mechanisms mediating BFA toxicity, we conducted a genome-wide haploid genetic screen that led to
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