B5683
倍他洛尔 盐酸盐
>98% (HPLC), calcium channel blocker, solid
别名:
SL 75212
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关于此项目
经验公式（希尔记法）:
C18H29NO3 · HCl
化学文摘社编号:
分子量:
343.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
264-384-3
MDL number:
产品名称
倍他洛尔 盐酸盐, >98% (HPLC)
InChI
1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H
InChI key
CHDPSNLJFOQTRK-UHFFFAOYSA-N
SMILES string
Cl[H].CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1
assay
>98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: soluble 36 mg/mL
originator
Alcon
Quality Level
Gene Information
human ... ADRB1(153)
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Application
Betaxolol hydrochloride has been used as a β1 blocking agent:
- for the preparation of crystals of (R,S)-betaxolol (BE-IV).
- to treat mammalian cells prior cell stimulation experiments.
- to study the solid structure of metoprolol.
Biochem/physiol Actions
Betaxolol hydrochloride has the ability to block calcium channels. Betaxolol is a selective β1 adrenoreceptor antagonist. It has neuroprotective effects on retinal neurons.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Alcon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Yi Huang et al.
International journal of nanomedicine, 12, 1731-1745 (2017-03-11)
As a novel ion-exchange carrier with high surface area and excellent exchangeability, montmorillonite (Mt) was intercalated with betaxolol hydrochloride (BH) to form a nanocomposite and then encapsulated by liposomes (Mt-BH-LPs) for an ophthalmic drug-delivery system. The Mt-BH and Mt-BH-LPs were
Investigating Differences and Similarities between Betaxolol Polymorphs
Rossi P, et al.
Crystals, 9(10), 509-509 (2019)
Patrizia Rossi et al.
Acta crystallographica. Section C, Structural chemistry, 75(Pt 2), 87-96 (2019-02-06)
Metoprolol {systematic name: (RS)-1-isopropylamino-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol}, C15H25NO3, is a cardioselective β1-adrenergic blocking agent that shares part of its molecular skeleton with a large number of other β-blockers. Results from its solid-state characterization by single-crystal and variable-temperature powder X-ray diffraction and differential scanning
M Q Rahman et al.
The British journal of ophthalmology, 95(7), 966-970 (2011-01-25)
To report the persistence of glaucoma medical therapy in a database of 1006 patients with ocular hypertension (OHT), normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) attending the Glaucoma Clinic at Glasgow Royal Infirmary, Glasgow, UK. Analyses have been
Ana Franky Carvalho et al.
Neuroscience letters, 500(1), 82-85 (2011-06-23)
The cannabinoid system is known to interact with a variety of neuromodulators in the central nervous system and impacts diverse behaviors. Previous studies have demonstrated that limbic norepinephrine is a critical determinant in the behavioral expression of cannabinoid-induced aversion. The
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