B5556
Bay 11-7082
≥98% (HPLC), powder, NF-kB/TNF-α inhibitor
别名:
（E）-3-（4-甲苯磺酰基）-2-丙烯腈
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H9NO2S
化学文摘社编号:
分子量:
207.25
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Bay 11-7082, ≥98% (HPLC), powder
SMILES string
Cc1ccc(cc1)S(=O)(=O)\C=C\C#N
InChI key
DOEWDSDBFRHVAP-KRXBUXKQSA-N
InChI
1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >20 mg/mL
H2O: insoluble
Quality Level
Application
Bay 11-7082已用作：
- 细胞核因子kappa B(NF-kB)抑制剂，验证NF-kB信号通路在白介素(IL)-8产生中的作用
- 核因子kappa B(NF-kB)抑制剂，研究NF-kB活化在猪鼻支原体诱导上皮-间充质转化(EMT)和细胞迁移中的作用
- NOD样受体热蛋白结构域相关蛋白3(NLRP3)选择性抑制剂，研究其对造血干细胞移植小鼠的肝脏炎症的作用
Biochem/physiol Actions
Bay 11-7082 是细胞因子诱导的 IκB-α 磷酸化的抑制剂。
Bay 11-7082可作为NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎性小体信号通路的选择性抑制剂。除了抑制核因子-kappa B(NF-kB)之外，Bay 11-7082还可诱发无核红细胞、人类T细胞白血病病毒I型(HTLV-I)感染T细胞系和原代成人T细胞白血病细胞的凋亡。
Features and Benefits
该化合物是基因调控研究的特色产品。点击此处查看更多特色基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
P Luz-Crawford et al.
Annals of the rheumatic diseases, 75(12), 2166-2174 (2016-03-11)
To define how peroxisome proliferator-activated receptor (PPAR) β/δ expression level in mesenchymal stem cells (MSCs) could predict and direct both their immunosuppressive and therapeutic properties. PPARβ/δ interacts with factors such as nuclear factor-kappa B (NF-κB) and regulates the expression of
Mycoplasma hyorhinis induces epithelial-mesenchymal transition in gastric cancer cell MGC803 via TLR4-NF-kappaB signaling
Duan H, et al.
Cancer Letters, 354(2), 447-454 (2014)
The role of NF-kappa B signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264. 7 cells
Kim HR, et al.
Toxicology Letters, 233(2), 148-155 (2015)
Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells
Mori N, et al.
Blood, 100(5), 1828-1834 (2002)
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
Juliana C, et al.
The Journal of Biological Chemistry, 285(13), 9792-9802 (2010)
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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