所有图片(1)
About This Item
经验公式（希尔记法）:
C15H20BrN5O13P2
CAS号:
分子量:
620.20
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
推荐产品
质量水平
方案
85% (HPLC)
表单
lyophilized powder
颜色
white
溶解性
H2O: 5 mg/mL
储存温度
−20°C
SMILES字符串
Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)OP(=O)(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)O[C@H]4[C@H]3O)c(Br)nc12
InChI
1S/C15H20BrN5O13P2/c16-15-20-6-11(17)18-3-19-12(6)21(15)13-9(25)10-5(30-13)2-29-35(26,27)34-36(28,32-10)33-14-8(24)7(23)4(1-22)31-14/h3-5,7-10,13-14,22-25H,1-2H2,(H,26,27)(H2,17,18,19)/t4-,5-,7-,8-,9-,10-,13-,14+,36?/m1/s1
InChI key
PLQQKRPSINJWTK-VNMBDIRDSA-N
生化/生理作用
环二磷酸腺苷核糖 (cADPR) 的拮抗剂，β-NAD+ 的内源性代谢物。cADPR 已显示出可调节内质网和肌浆网的钙释放。在细胞中，cADPR 是由 ADP-核糖基环化酶或淋巴细胞分化抗原 CD38 合成。
外形
含 10-20% 磷酸钠缓冲盐的冻干粉
制备说明
酶法制备
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
H C Lee et al.
Advances in experimental medicine and biology, 419, 411-419 (1997-01-01)
Mobilization of internal Ca+2 is an important signaling mechanism in cells. In addition to the inositol trisphosphate pathway, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide (NAADP) have been shown to mobilize Ca+2 via independent mechanisms. Although the structures of
H C Lee
Cell biochemistry and biophysics, 28(1), 1-17 (1997-12-05)
Ca2+ mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+ messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+ release activators, which mobilize internal Ca2+ stores via mechanisms totally
A De Flora et al.
The international journal of biochemistry & cell biology, 29(10), 1149-1166 (1998-01-23)
CD38 was first identified as a lymphocyte differentiation antigen that showed typical properties of an orphan receptor involved in many programs of cell proliferation and activation. However, CD38 proved also to be a bifunctional ectoenzyme that catalyzes the transient formation
A H Guse et al.
Journal of immunology (Baltimore, Md. : 1950), 155(7), 3353-3359 (1995-10-01)
Ca2+ release from intracellular stores is one of the major events transducing extracellular signals into living cells. Recently, a metabolite of nicotinamide adenine dinucleotide+ (NAD+), termed "cyclic adenosine diphosphate-ribose" (cADPr), has been described to release Ca2+ from caffeine-sensitive internal stores
S Iino et al.
Circulation research, 81(5), 879-884 (1997-11-14)
Although it is becoming widely accepted that cADP-ribose (cADPR) can regulate calcium release from the endoplasmic reticulum in sea urchin eggs and in a variety of mammalian cell types, it remains controversial whether this substance might influence calcium release during
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