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Merck
CN
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文件

安全信息

B5150

Sigma-Aldrich

杆菌肽 锌盐

from Bacillus licheniformis, ~70,000 U/g

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别名:
杆菌肽锌
经验公式（希尔记法）:
C66H101N17O16SZn
CAS号:
1405-89-6
分子量:
1486.07
EC 号:
215-787-8
MDL编号:
MFCD00130598
UNSPSC代码:
51101500
PubChem化学物质编号:
57653938
NACRES:
NA.85

生物来源

Bacillus licheniformis

质量水平

200

形式

powder

比活

~70,000 U/g

mp

250 °C (dec.) (lit.)

抗生素抗菌谱

Gram-positive bacteria

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES字符串

[Zn++].CCC(C)C(N)C1=NCC(S1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC([O-])=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC

InChI

1S/C66H103N17O16S.Zn/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90;/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88);/q;+2/p-2/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-;/m0./s1

InChI key

NKULICGUDKGGRL-FCHFGNCGSA-L

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相关类别

一般描述

Chemical structure: peptide

应用

Bacitracin zinc salt is a peptide antibiotic used to study dysruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is used to study the biosynthesis of sterols and squalene.

生化/生理作用

Bacitracin is a protease inhibitor. Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

分析证书(COA)

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Mechanism of bacitracin action: a specific lipid-peptide interaction.
D R Storm
Annals of the New York Academy of Sciences, 235(0), 387-398 (1974-05-10)
Tritium--hydrogen exchange of bacitracin A. Evidence for an intramolecular hydrogen bond.
R E Galardy et al.
Biochemistry, 10(13), 2429-2436 (1971-06-22)
Bacitracin: an inhibitor of the dephosphorylation of lipid pyrophosphate, an intermediate in the biosynthesis of the peptidoglycan of bacterial cell walls.
G Siewert et al.
Proceedings of the National Academy of Sciences of the United States of America, 57(3), 767-773 (1967-03-01)
M Ammar Zafar et al.
mBio, 10(3) (2019-06-20)
Host-to-host transmission is a necessary but poorly understood aspect of microbial pathogenesis. Herein, we screened a genomic library of mutants of the leading respiratory pathogen Streptococcus pneumoniae generated by mariner transposon mutagenesis (Tn-Seq) to identify genes contributing to its exit
T M Fong et al.
The Journal of biological chemistry, 269(4), 2728-2732 (1994-01-28)
Previous studies suggested that the antagonist binding site in the neurokinin-1 receptor is composed of phylogenetically conserved residues, while phylogenetically divergent residues affect the conformation of the binding site. To test this hypothesis, we investigated the role of conserved residues
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