生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 345 kDa
种属反应性
mouse (predicted), rat (predicted), human
浓度
~1 mg/mL
技术
immunoprecipitation (IP): 5-10 μg using HEK 293-T cell lysates
microarray: suitable
western blot: 2-4 μg/mL using U2OS total cell extracts
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TP53BP1(7158)
mouse ... Trp53bp1(27223)
rat ... Tp53bp1(296099)
一般描述
Tumor protein p53 binding protein (T153BP1) is mapped to human chromosome 15q15.3. It has methylated histone-binding module and tandem tudor domains.
免疫原
synthetic peptide corresponding to amino acids 1955-1972 of human 53BP1, conjugated to KLH via an N-terminal added cysteine residue. This sequence is conserved in mouse, and differs from rat by one amino acid
应用
Anti-53BP1 (C-terminal) antibody produced in rabbit has been used in western blotting and immunoprecipitation
生化/生理作用
Tumor protein p53 binding protein (T153BP1) has a close link to ataxia-telangiectasia mutated (ATM)-regulated events. 53BP1 becomes phosphorylated by ATM in a DNA damage-dependent manner suggesting that it participates in propagating the ATM signaling to its downstream effectors. T153BP1 also plays a key role in DNA repair by mediating nonhomologous end-joining (NHEJ) near double stranded breaks (DSBs). Fusion of T153BP1 with platelet-derived growth factor receptor beta (PDGFRβ) is implicated in a type of myeloproliferative disorder accompanied with eosinophilia.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Role of 53BP1 oligomerization in regulating double-strand break repair
Lottersberger F, et al.
Proceedings of the National Academy of Sciences of the USA, 110(6), 2146-2151 (2013)
Genomic landscape of liposarcoma
Kanojia D, et al.
Testing, 6(40), 42429-42429 (2015)
p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with at (5; 15)(q33; q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
Grand FH, et al.
Cancer Research, 64(20), 7216-7219 (2004)
Michael T Perfetti et al.
ACS chemical biology, 10(4), 1072-1081 (2015-01-16)
Improving our understanding of the role of chromatin regulators in the initiation, development, and suppression of cancer and other devastating diseases is critical, as they are integral players in regulating DNA integrity and gene expression. Developing small molecule inhibitors for
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
Botuyan MV, et al.
Cell, 127(7), 1361-1373 (2006)
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