质量水平
检测方案
≥98% (HPLC)
形式
solid
储存条件
desiccated
protect from light
under inert gas
颜色
orange
溶解性
H2O: 10 mg/mL
储存温度
−20°C
SMILES字符串
Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2
InChI
1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H
InChI key
UYYPMQOFLJHJAW-UHFFFAOYSA-N
生化/生理作用
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.
注意
Product is air sensitive, store under inert gas.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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