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安全信息

B4272

Sigma-Aldrich

Bombesin acetate salt hydrate

≥97% (HPLC)

别名:

pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

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About This Item

经验公式（希尔记法）:
C71H110N24O18S · xC2H4O2 · yH2O
分子量:
1619.85 (anhydrous free base basis)
Beilstein:
9611365
MDL编号:
MFCD00167514
UNSPSC代码:
12352209
PubChem化学物质编号:
24891763
NACRES:
NA.32

质量水平

200

方案

≥97% (HPLC)

表单

powder

储存温度

−20°C

SMILES字符串

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)C(C)C)C(N)=O

InChI

1S/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-56(100)87-51(28-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-49(26-38-29-80-41-13-10-9-12-40(38)41)66(109)84-37(7)60(103)95-58(36(5)6)70(113)82-32-57(101)86-50(27-39-30-78-33-83-39)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8/h9-10,12-13,29-30,33-37,42-51,58,80H,11,14-28,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,83)(H,81,104)(H,82,113)(H,84,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79)/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-/m0/s1

InChI key

QXZBMSIDSOZZHK-DOPDSADYSA-N

基因信息

human ... GRPR(2925)

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Amino Acid Sequence

Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

一般描述

Gastrin releasing peptide receptor (GRP-R) belongs to the G protein-coupled receptors (GPCR) family. The gene for the gastrin‐releasing peptide receptor is located on the short arm of human X chromosome.

应用

Bombesin acetate salt hydrate has been used in immunohistochemical methods and food intake measurements.

生化/生理作用

Bombesin/gastrin releasing peptide (BN/GRP) serves as an autocrine growth factor in small cell lung cancer (SCLC). Overexpression of gastrin releasing peptide receptor (GRP-R) is associated with neuroblastoma tumor aggressiveness. GRP-R modulates the important enzymes, that participates in glucose metabolism. Bombesin, a pulmonary growth factor helps to satisfy the conditions for autocrine stimulation.
Tetradecapeptide originally isolated from the skin of the frog Bombina bombina. Bombesin acts at specific brain nuclei to inhibit food intake. It also increases blood glucose levels.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000384646
0000363445
0000363444
0000363445
0000363444

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Bombesin microinjection into the basolateral amygdala influences feeding behavior in the rat
Vigh J, et al.
Brain Research, 847(2), 253-261 (1999)
Céléna Dubuc et al.
Bioorganic & medicinal chemistry letters, 18(7), 2424-2427 (2008-03-11)
Sulfonated aluminum phthalocyanines (AlPcS) are potent photosensitizers for the photodynamic therapy (PDT) of cancer. In this study we evaluate the possibility to improve the efficacy of AlPcS-PDT for prostate cancer by targeting tetrasulfonated aluminum phthalocyanines (AlPcS(4)) to the gastrin-releasing peptide
[Psi13, 14] bombesin analogues inhibit growth of small cell lung cancer in vitro and in vivo
Mahmoud S, et al.
Cancer research, 51(7), 1798-1802 (1991)
I Schulz et al.
Biological chemistry, 380(7-8), 903-908 (1999-09-24)
In pancreatic acinar cells stimulation of different intracellular pathways leads to different patterns of Ca2+ signaling. Bombesin induces activation of both phosphatidylinositol 4,5-bisphosphate (PIP2)-specific phospholipase C (PLC) and phospholipase D (PLD). The latter leads to generation of diacylglycerol (DAG) in
H Plamondon et al.
Regulatory peptides, 47(2), 133-140 (1993-09-03)
Bombesin (Bn), a peptide of amphibian origin, has been shown to induce hyperglycemia when injected centrally. In recent years, two families of Bn-like peptides have been isolated from the mammalian brain: the gastrin releasing peptide (GRP) type and neuromedin B
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