质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white
溶解性
0.1 M acetic acid: 25 mg/mL, clear, colorless
UniProt登记号
储存温度
−20°C
InChI
1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI key
QXZGBUJJYSLZLT-FDISYFBBSA-N
基因信息
human ... KNG1 (includes EG:3827)
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相关类别
Amino Acid Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
应用
Bradykinin acetate salt has been used:
- to stimulate the contraction of guinea pig ileum
- as a contractile agent in fibroblasts
- In the stimulation of endothelium of human subcutaneous artery
- To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15
生化/生理作用
缓激肽是一种促炎肽,通过 G-蛋白质偶联受体进行作用。它活化鞘脂类的代谢。经缓激肽处理的成纤维细胞的神经酰胺分泌量会有快速而重大的增长,随后鞘氨醇含量也会短暂上升。这种肽也会通过使中性糖脂快速移动来增加细胞的神经酰胺含量。缓激肽在体液和电解质平衡的调节、平滑肌收缩、血管舒张和毛细血管通透性方面都发挥着重要的作用。缓激肽增效剂本身不具有缓激肽活性,但能增强缓激肽的活性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Haptotaxis is cell type specific and limited by substrate adhesiveness
Cellular and Molecular Bioengineering, 8(4), 530-542 (2015)
The Journal of biological chemistry, 266(8), 4995-5003 (1991-03-15)
The modulation of neuronal adenylylcyclase by Ca2+, acting via calmodulin, is a long-established example of a positive interaction between the Ca2(+)-mobilizing and cAMP-generating systems. In the present study, concentrations of Ca2+ that stimulate brain adenylylcyclase inhibit the adenylylcyclase of NCB-20
Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide
Food And Chemical Toxicology, 120, 321-327 (2018)
American journal of human genetics, 92(3), 422-430 (2013-02-26)
Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of inherited neuropathies. Mutations in approximately 45 genes have been identified as being associated with CMT. Nevertheless, the genetic etiologies of at least 30% of CMTs have yet to be elucidated. Using a
PloS one, 8(2), e53773-e53773 (2013-02-08)
Attacks of hereditary angioedema (HAE) are unpredictable and, if affecting the upper airway, can be lethal. Icatibant is used for physician- or patient self-administered symptomatic treatment of HAE attacks in adults. Its mode of action includes disruption of the bradykinin
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