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安全信息

B3259

Sigma-Aldrich

缓激肽 乙酸盐

powder, ≥98% (HPLC)

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About This Item

经验公式（希尔记法）:
C50H73N15O11 · xC2H4O2
CAS号:
6846-03-3
分子量:
1060.21 (free base basis)
EC 号:
227-781-2
MDL编号:
MFCD00076258
UNSPSC代码:
12352106
NACRES:
NA.32
方案:
≥98% (HPLC)
表单:
powder
溶解性:
0.1 M acetic acid: 25 mg/mL, clear, colorless

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white

溶解性

0.1 M acetic acid: 25 mg/mL, clear, colorless

UniProt登记号

P01042

储存温度

−20°C

SMILES字符串

N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N

InChI

1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

InChI key

QXZGBUJJYSLZLT-FDISYFBBSA-N

基因信息

human ... KNG1 (includes EG:3827)

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Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

应用

Bradykinin acetate salt has been used:
  • to stimulate the contraction of guinea pig ileum
  • as a contractile agent in fibroblasts
  • In the stimulation of endothelium of human subcutaneous artery
  • To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15

生化/生理作用

激活痛觉受体；引起平滑肌收缩；激活 Ca2+ 依赖性一氧化氮合成酶；增加毛细血管通透性。
缓激肽是一种促炎肽，通过 G-蛋白质偶联受体进行作用。它活化鞘脂类的代谢。经缓激肽处理的成纤维细胞的神经酰胺分泌量会有快速而重大的增长，随后鞘氨醇含量也会短暂上升。这种肽也会通过使中性糖脂快速移动来增加细胞的神经酰胺含量。缓激肽在体液和电解质平衡的调节、平滑肌收缩、血管舒张和毛细血管通透性方面都发挥着重要的作用。缓激肽增效剂本身不具有缓激肽活性，但能增强缓激肽的活性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL3438
BCCK2555
BCCH8393
BCCG0917
BCCD2067

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