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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous glycerol solution
分子量
antigen 15 kDa
种属反应性
mouse
技术
microarray: suitable
western blot: suitable using mouse L929 cells treated with TNF-α
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此商品 | 100202 | 110983 | 543897 |
|---|---|---|---|
| technique(s) UV/Vis spectroscopy: suitable | technique(s) GC-HS: suitable | technique(s) gas chromatography (GC): suitable | technique(s) HPLC: suitable |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form liquid | form liquid | form liquid | form liquid |
| UV absorption λ: 270 nm Amax: ≤0.60, λ: 290 nm Amax: ≤0.10, λ: 330 nm Amax: ≤0.01, λ: 275 nm Amax: ≤0.22, λ: 300 nm Amax: ≤0.05 | UV absorption - | UV absorption - | UV absorption - |
| expl. lim. 15.2 % | expl. lim. 15.2 % | expl. lim. 15.2 % | expl. lim. 15.2 % |
免疫原
synthetic peptide corresponding to N-terminal of cleavage site [59/60] of mouse BID.
应用
Polyclonal anti-BID antibody produced in rabbit is suitable for western blotting by using mouse L929 cells treated with TNF-α. It is also suitable for microarray.
生化/生理作用
The protein encoded by this gene is a member of the BCL-2 family of cell death regulators and is localized on to chromosome 22q11.2. BID is activated by caspase 8 in response to Fas/TNF-R1 receptor activation. Activated BID then translocated to mitochondria where it induces cytochrome c release, which in turn activates downstream caspases. It is a BH3 interacting death domain that heterodimerizes with either agonist BAX or antagonist BCL2. BID initiates apoptosis by binding to regulatory sites on prosurvival BCL2 proteins to directly neutralize their function. Additionally, BID interacts with cathepsins play an important role in the actions of Camptothecin on breast cancer cells.
外形
Supplied as a solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
法规信息
新产品
M Lamparska-Przybysz et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 56 Suppl 3, 159-179 (2005-08-04)
The details of molecular switching points between apoptosis and autophagy in tumor cells have still not been fully elucidated. This study focused on the role of cathepsin B and its substrate, BID as molecular links between apoptosis and autophagy in
T K Footz et al.
Genomics, 51(3), 472-475 (1998-08-29)
Cat eye syndrome (CES) is associated with a duplication of a segment of human chromosome 22q11.2. Only one gene, ATP6E, has been previously mapped to this duplicated region. We now report the mapping of the human homologue of the apoptotic
H Li et al.
Cell, 94(4), 491-501 (1998-09-04)
We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway. While full-length BID is localized in cytosol, truncated BID (tBID) translocates to mitochondria and thus
Vijay Agarwal et al.
International journal of oncology, 42(3), 1088-1092 (2013-01-23)
We have previously shown that specific COX-2 inhibitors, including DuP 697, have anti-proliferative effects on mesothelioma cells and potentiate the cytotoxicity of pemetrexed. Here, we used a novel proteomic approach to explore the mechanism of action of this agent. COX-2-positive
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